Efficacy of intervertebral disc regeneration with stem cells - a systematic review and meta-analysis of animal controlled trials

Gene
Zhen WangWenchun Qu

Abstract

Management of intervertebral disc (IVD) degenerative disease is challenging, as it is accompanied by irreversible loss of IVD cells. Stem cell transplantation to the disc has shown promise in decelerating or arresting the degenerative process. Multiple pre-clinical animal trials have been conducted, but with conflicting outcomes. To assess the effect of stem cell transplantation, a systematic review and meta-analysis was performed. A comprehensive literature search was conducted through Week 3, 2015. Inclusion criteria consisted of controlled animal trials. Two reviewers screened abstracts and full texts. Disagreements were resolved by a third reviewer. Random effects models were constructed to pool standardized mean difference (SMD). Twenty two studies were included; nine of which were randomized. Statistically significant differences were found with the stem cell group exhibiting increased disc height index (SMD=3.64, 95% confidence interval (CI): 2.49, 4.78; p<0.001), increased MRI T2 signal intensity (SMD=2.28, 95% CI: 1.48, 3.08; p<0.001), increased Type II collagen mRNA expression (SMD=3.68, 95% CI: 1.66, 5.70; p<0.001), and decreased histologic disc degeneration grade (SMD=-2.97, 95% CI: -3.97, -1.97; p<0.001). There was...Continue Reading

References

Nov 1, 1996·The Journal of Bone and Joint Surgery. British Volume·M A AdamsP Dolan
Apr 2, 1999·Science·M F PittengerD R Marshak
Oct 18, 2002·Arthritis and Rheumatism·William E B JohnsonSally Roberts
Mar 11, 2004·The International Journal of Biochemistry & Cell Biology·Frank P Barry, J Mary Murphy
May 27, 2005·Neurosurgical Focus·William C Welch, Peter C Gerszten
Jan 2, 2007·The Spine Journal : Official Journal of the North American Spine Society·Hasan MirzaiAdem Bursali
May 2, 2007·Arthritis and Rheumatism·Tara W Strine, Jennifer M Hootman
Sep 4, 2007·Trends in Neurosciences·Emily SenaMalcolm Macleod
Jan 19, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Akihiko HiyamaDaisuke Sakai
Feb 14, 2008·JAMA : the Journal of the American Medical Association·Brook I MartinSean D Sullivan
Jun 27, 2008·Spine·Pepijn D D M RoelofsMaurits W van Tulder
Aug 30, 2008·Arthritis Research & Therapy·Devina PurmessurJudith A Hoyland
Aug 30, 2008·Regenerative Medicine·N S KalsonJ A Hoyland
Jul 9, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Fan YangKenneth M C Cheung
Jul 20, 2010·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Marienke van MiddelkoopMaurits W van Tulder
Sep 15, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kenji SeriganoJoji Mochida
Jun 8, 2011·Annals of the Rheumatic Diseases·Gregory LivshitsFrances M K Williams
Jan 11, 2012·Arthritis and Rheumatism·Damian HoyRachelle Buchbinder
May 3, 2012·Stem Cells International·Andreas SchmittStefan Buchmann
May 31, 2012·Radiologic Clinics of North America·Nikolai Bogduk
Jul 4, 2012·Photomedicine and Laser Surgery·Ho Jang, Hyunju Lee
Sep 28, 2012·The Journal of Bone and Joint Surgery. British Volume·S P F HughesS Roberts
Nov 16, 2013·Current Pain and Headache Reports·Hamish T J GilbertStephen M Richardson
Nov 29, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hiroaki HirataKotaro Nishida
Feb 1, 2014·Annals of the Rheumatic Diseases·Damian HoyRachelle Buchbinder

❮ Previous
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Citations

Nov 14, 2015·Tissue Engineering. Part C, Methods·Graciosa Q TeixeiraCornelia Neidlinger-Wilke
Mar 26, 2016·Spine·Kee D Kim
Aug 25, 2015·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Kivanc AtesokScott A Rodeo
Oct 29, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Svenja Illien-JüngerJames C Iatridis
Oct 5, 2017·The Journal of Bone and Joint Surgery. American Volume·Sandra ReitmaierHendrik Schmidt
Jun 2, 2016·World Journal of Stem Cells·Gianluca VadalàVincenzo Denaro
Dec 24, 2019·Pain Practice : the Official Journal of World Institute of Pain·Mehul J DesaiJoanne Borg-Stein
Jul 21, 2020·Expert Review of Neurotherapeutics·Ali MoghaddamjouMichael G Fehlings
Feb 21, 2019·PM & R : the Journal of Injury, Function, and Rehabilitation·Hai NieAndre J van Wijnen
Mar 16, 2017·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Christopher LudtkaFelix Goehre
Jan 1, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Luke LawWenchun Qu
Aug 25, 2018·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·G W OmlorW Richter
Jul 31, 2019·Current Pain and Headache Reports·Ivan UritsVwaire Orhurhu
Jun 4, 2019·Global Spine Journal·Patrick C HsiehJeffrey C Wang
Apr 6, 2021·Frontiers in Medicine·Abed El-Hakim El-KadiryRiam Shammaa

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