PMID: 9184858Jan 1, 1996Paper

Efficacy of intra-arterial norcantharidin in suppressing tumour 14C-labelled glucose oxidative metabolism in rat Morris hepatoma

HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery
P MackL Y Cheng

Abstract

Norcantharidin is the demethylated form of Cantharidin, which is the active ingredient of the blister beetle, Mylabris, a long used Chinese traditional medicine. Though not well publicized outside China, Norcantharidin is known to possess significant anti-hepatoma activity, and is relatively free from side effects. In the present study, glucose oxidation in tumour and liver tissue slices harvested from hepatoma-bearing animals was quantified by measuring the radioactivity of 14C-labelled CO2 released from 14C-glucose in oxygen-enriched incubation medium. Results were expressed as a tumour/liver ratio. For comparison, treatments with Norcantharidin, Adriamycin and with hepatic artery ligation were studied. The mean tumour/liver ratio was 4.2 +/- 2.2 in untreated controls, but dropped significantly to 2.3 +/- 0.5 (p < 0.05) with intra-arterial Norcantharidin (0.5 mg/kg) and to 2.3 +/- 0.7 (p < 0.05) with intra-arterial Adriamycin (2.4 mg/kg), and to 2.2 +/- 0.7 (p < 0.05) with hepatic artery ligation. However, with intravenous Adriamycin at 2.4 mg/kg, the mean tumour/liver ratio was reduced to only 3.5 +/- 2.0 and was not significantly different from untreated controls. It is concluded that intra-arterial Norcantharidin is as eff...Continue Reading

Citations

Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Yan-Nian ChenShih-Lan Hsu
Nov 4, 2000·Archives of Pharmacal Research·M Y AhnY S Kim
Sep 15, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Jun GuoYanjun Zeng
May 29, 2013·The American Journal of Chinese Medicine·Sansan ChenJinlong Li
Apr 14, 2016·Journal of Cancer Research and Therapeutics·Qiu CuiYanjun Zeng
Apr 16, 2005·World Journal of Gastroenterology : WJG·Yue-Zu FanCun-Qiu Chen
Jun 11, 2011·Insect Biochemistry and Molecular Biology·Norman A RatcliffePatricia Azambuja

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