Efficacy of intra-articular hyaluronan (Synvisc(R)) for the treatment of osteoarthritis affecting the first metatarsophalangeal joint of the foot (hallux limitus): study protocol for a randomised placebo controlled trial.

Journal of Foot and Ankle Research
Shannon E MunteanuJason Deluca

Abstract

Osteoarthritis of the first metatarsophalangeal joint (MPJ) of the foot, termed hallux limitus, is common and painful. Numerous non-surgical interventions have been proposed for this disorder, however there is limited evidence for their efficacy. Intra-articular injections of hyaluronan have shown beneficial effects in case-series and clinical trials for the treatment of osteoarthritis of the first metatarsophalangeal joint. However, no study has evaluated the efficacy of this form of treatment using a randomised placebo controlled trial. This article describes the design of a randomised placebo controlled trial to evaluate the efficacy of intra-articular hyaluronan (Synvisc(R)) to reduce pain and improve function in people with hallux limitus. One hundred and fifty community-dwelling men and women aged 18 years and over with hallux limitus (who satisfy inclusion and exclusion criteria) will be recruited.Participants will be randomised, using a computer-generated random number sequence, to receive a single intra-articular injection of up to 1 ml hyaluronan (Synvisc(R)) or sterile saline (placebo) into the first MPJ. The injections will be performed by an interventional radiologist using fluoroscopy to ensure accurate deposition...Continue Reading

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Citations

Oct 27, 2009·Journal of Foot and Ankle Research·Shannon E MunteanuLisa A Scott
Nov 13, 2009·Journal of Foot and Ankle Research·Mike J PotterKarl B Landorf
Jan 25, 2011·Journal of Foot and Ankle Research·Matthew P CotchettAnita Raspovic
Jun 1, 2014·PM & R : the Journal of Injury, Function, and Rehabilitation·Kenneth J HuntGordon Matheson
Jul 3, 2015·American Journal of Physical Medicine & Rehabilitation·Tan X JerilynShannon E Munteanu
May 25, 2012·Arthritis Care & Research·Shaun M BerginHylton B Menz
Sep 9, 2010·The Cochrane Database of Systematic Reviews·Gerard V ZammitMark F Gilheany

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