Efficacy of intra-articular hypertonic dextrose prolotherapy versus normal saline for knee osteoarthritis: a protocol for a triple-blinded randomized controlled trial

BMC Complementary and Alternative Medicine
Regina Wing Shan SitSamuel Yeung Shan Wong

Abstract

Knee Osteoarthritis (KOA) is a very common condition with prevalence rising with age. It is a major contributor to global disability and has a large socioeconomic burden worldwide. Conservative therapies have marginal effectiveness, and surgery is reserved for severe symptomatic KOA. Dextrose Prolotherapy (DPT) is an evidence-based injection-based therapy for chronic musculoskeletal conditions including KOA. The standard "whole joint" injection method includes intra-articular injection and multiple extra-articular injections at soft tissue bony attachments. The procedure is painful and requires intensive procedural training often unavailable in conventional medical education, which potentially limits access. Intra-articular injection offers the possibility of a less painful, more accessible treatment. The aim of this project is to assess the clinical efficacy of intra-articular injection of DPT versus normal saline (NS) for KOA. Seventy-six participants with KOA will be recruited from the community. We will conduct a single center, parallel group, superiority randomized controlled trial comparing DPT and NS injections, with blinding of physician, participants, outcome assessors and statisticians. Each group will receive injecti...Continue Reading

References

Feb 11, 1999·Journal of Clinical Epidemiology·W N KernanR I Horwitz
Feb 28, 2002·Lancet·Kenneth F Schulz, David A Grimes
Dec 1, 1957·Annals of the Rheumatic Diseases·J H KELLGREN, J S LAWRENCE
Mar 17, 2004·Controlled Clinical Trials·Heejung BangClarence E Davis
Aug 18, 2004·Rejuvenation Research·T AignerJ Buckwalter
Sep 1, 1950·Archives of Surgery·T G RANDOLPHC K WALTER
Aug 12, 2005·Current Opinion in Rheumatology·David T Felson
Feb 24, 2006·The New England Journal of Medicine·David T Felson
Jul 11, 2007·Statistical Methods in Medical Research·Stef van Buuren
Jan 1, 2008·Arthritis and Rheumatism·Reva C LawrenceUNKNOWN National Arthritis Data Workgroup
Mar 2, 2010·Primary Care·David RabagoAleksandra Zgierska
Apr 9, 2010·International Journal of Rheumatic Diseases·Ingrid HuttonNicola Dalbeth
Jul 28, 2010·Arthritis Care & Research·Gillian A HawkerWendy Lou
Mar 9, 2012·Lancet·Andrew J CarrDavid J Beard
Apr 21, 2012·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·David RabagoJeffrey J Patterson
Jul 5, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Richard DumaisMathieu Bélanger
Jan 9, 2013·Annals of Internal Medicine·An-Wen ChanDavid Moher
May 22, 2013·Annals of Family Medicine·David RabagoAleksandra Zgierska
Oct 26, 2013·Seminars in Arthritis and Rheumatism·Nasimah MaricarTerence W O'Neill
Mar 15, 2014·Annals of the Rheumatic Diseases·Philip G ConaghanUNKNOWN EULAR osteoarthritis ad hoc committee
May 23, 2014·Nature Reviews. Rheumatology·David T Felson
Apr 9, 2016·PM & R : the Journal of Injury, Function, and Rehabilitation·Gastón Andrés TopolDavid Rabago
Oct 30, 2016·Physical Medicine and Rehabilitation Clinics of North America·Kenneth Dean ReevesDavid P Rabago
Mar 24, 2017·British Medical Bulletin·Fadi HassanNicola Maffulli

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Citations

Apr 1, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Alketa T SertEmel Ozcan
Aug 11, 2020·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Zahra RezasoltaniFateme Abdorrazaghi
Oct 23, 2020·Arthritis Care & Research·Grace ColemanDaniel K White
Dec 17, 2020·Neurophysiologie clinique = Clinical neurophysiology·Sirous AziziAfsaneh Dadarkhah

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