Efficacy of intra-articular polynucleotides in the treatment of knee osteoarthritis: a randomized, double-blind clinical trial.

Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA
Roberto VanelliFrancesco Benazzo

Abstract

This randomized, double-blind clinical trial was conducted over 16 weeks to assess the efficacy and safety profile of intra-articular polynucleotides gel injections in the treatment of knee osteoarthritis associated with persistent knee pain. 60 patients were enrolled and randomized to receive intra-articular polynucleotides (n = 30) or hyaluronan (n = 30); patients received five weekly intra-articular knee injections and the follow-up period was 3 months after the end of treatment. Primary endpoint was to determine polynucleotides (PN) efficacy in reducing knee pain at the end of the study, over baseline value and over standard hyaluronan viscosupplementation (HA). Pain levels were measured using a 0-10 cm Visual Analogue Scale (VAS). Secondary endpoints included Knee Osteoarthritis Outcome Score (KOOS), NSAIDs consumption, crackling during movement and articular mobility limitation. The mean global VAS pain decreased from 5.7 + or - 1.9 cm (T0) to 1.9 + or - 1.5 cm (T16) in polynucleotide group and from 4.9 + or - 2.0 cm (T0) to 2.1 + or - 1.4 cm (T16) in hyaluronan group. The reduction in pain was statistically significant for both groups. KOOS increases from baseline values were statistically significant in both groups. No ...Continue Reading

References

Aug 12, 1998·The Journal of Orthopaedic and Sports Physical Therapy·E M RoosB D Beynnon
Jun 23, 1999·Cell Biochemistry and Function·P SiniC Balduini
Jun 13, 2003·Health and Quality of Life Outcomes·Ewa M Roos, Sören Toksvig-Larsen
Nov 14, 2003·Health and Quality of Life Outcomes·Ewa M Roos, L Stefan Lohmander
Dec 18, 2003·JAMA : the Journal of the American Medical Association·Grace H LoDavid T Felson
Apr 13, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Jasmin ArrichMarcus Müllner
Apr 21, 2006·The Cochrane Database of Systematic Reviews·N BellamyG Wells
Apr 18, 2007·Annals of Internal Medicine·Stephan ReichenbachPeter Jüni
Oct 3, 2007·The Journal of Bone and Joint Surgery. American Volume·Gunnar KnutsenOddmund Johansen
Jun 18, 2009·Inflammation & Allergy Drug Targets·Robert E NewmanAlla Danilkovitch-Miagkova
Oct 13, 2009·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Dieter Van AsscheFrank P Luyten

❮ Previous
Next ❯

Citations

Jun 28, 2012·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Sascha ColenDaniël Haverkamp
Nov 1, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Elizaveta KonStefano Della Villa
May 25, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Olivia T ChengJianguo Cheng
Apr 12, 2018·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Dante DallariMilena Fini
May 14, 2016·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Nicola RaniDante Dallari
Dec 20, 2019·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Dante DallariMilena Fini
Apr 16, 2018·Inflammation·Jonathan M BekiszBruce N Cronstein
Aug 14, 2021·Tissue Engineering and Regenerative Medicine·Jung-Taek HwangJiss Joseph Panakkal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.