Efficacy of intralesionally administered cisplatin-impregnated biodegradable polymer for the treatment of 9L gliosarcoma in the rat

Neurosurgery
K O LilleheiB Kleinschmidt-DeMasters

Abstract

Use of biodegradable polymers for the local delivery of chemotherapy is a promising new strategy in the treatment of high-grade gliomas. We examine the benefit of local delivery of cisplatin, via biodegradable polymer, in the treatment of intracranial glioma in rats. This treatment is compared against intralesionally administered free cisplatin and systemic cisplatin. The Fischer 344 9L gliosarcoma rat model was used with a cannula placed in the right frontal lobe. On Day 0, 5 x 10(3) 9L gliosarcoma cells were infused. Treatment was initiated on Day 7. In Experiment 1, polymer alone was infused intralesionally to rule out any inherent toxic or tumoricidal properties. In Experiment 2, polymer impregnated with 0.5, 5.0, and 25 mg/m2 cisplatin was infused intralesionally. In Experiment 3, the most effective dose of drug containing polymer was compared against a similar dose of intralesionally administered free cisplatin and the systemic administration of cisplatin. In Experiment 1, polymer alone demonstrated no inherent toxic or tumoricidal properties. In Experiment 2, polymer impregnated with 0.5 mg/m2 was 100% effective in eradicating intracranial tumor with minimal histological evidence of toxicity. At the 5.0 and 25 mg/m2 dose...Continue Reading

References

Jan 1, 1992·Cancer Chemotherapy and Pharmacology·M G DonelliM D'Incalci
Nov 1, 1990·Biomaterials·H Brem
Dec 1, 1984·The Journal of Pharmacy and Pharmacology·B HecquetP Cappelaere
Sep 1, 1980·Neurology·F H Hochberg, A Pruitt
Mar 1, 1982·Neurosurgery·J S Kroin, R D Penn
Nov 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R C StrawB E Powers

❮ Previous
Next ❯

Citations

Jun 2, 2016·Expert Opinion on Drug Delivery·Yuan-Yun TsengShih-Jung Liu
Apr 13, 2000·Cancer Control : Journal of the Moffitt Cancer Center·P Sampath, H Brem
May 15, 2008·Journal of the Royal Society, Interface·Yinghui Zhong, Ravi V Bellamkonda
Oct 29, 2020·Journal of the American Animal Hospital Association·Marije RisseladaB Duncan X Lascelles
May 10, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jake A GilbertHenry F Edelhauser
Jul 24, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·C BastiancichB Newland

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Bioremediation (ASM)

Bioremediation is the treatment and removal of harmful pollutants or contaminants through the use of microorganisms. Discover the latest research here.