Abstract
Adenosine, by intravenous and intrathecal routes, is known to alleviate various types of pain. However, the role of intrathecal adenosine in providing postoperative analgesia has not been confirmed. The aim of the present study was to evaluate the efficacy of intrathecal adenosine for postoperative pain relief, and to determine its role for pre-emptive analgesia. Ninety ASA I and II females, undergoing elective abdominal hysterectomy, were randomly divided into three groups of 30 patients each. Patients in the 'early adenosine' group received intrathecal adenosine 1,000 microg, 30 min before induction of anaesthesia. Patients in the 'late adenosine' group received the same dose before reversal of neuromuscular blockade. Control patients did not receive any test drug. A balanced general anaesthesia technique was used in all patients. Pain intensity scores using a visual analogue scale, sedation scores, time to first rescue analgesic and total morphine requirement were recorded. There was no significant difference in pain intensity scores, sedation scores, total morphine requirements and time to first rescue analgesic among the three groups. Intrathecal adenosine 1,000 microg is not effective as an analgesic for postoperative pai...Continue Reading
References
Sep 1, 1992·Anesthesiology·J KatzB F Shaw
Oct 1, 1995·British Journal of Pharmacology·A J Reeve, A H Dickenson
Nov 20, 1998·Anesthesiology·K RaneA Sollevi
Dec 23, 1998·British Journal of Anaesthesia·A Y MillarJ Kinsella
Apr 24, 1999·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·K S Filos, C E Vagianos
Aug 12, 2000·Acta Anaesthesiologica Scandinavica·K RaneM Segerdahl
Oct 6, 2000·Anesthesiology·I Kissin
Jan 1, 2003·Pain·Atsuo F FukunagaCharles W Stark
Apr 18, 2003·Acta Anaesthesiologica Scandinavica·K RaneM Segerdahl
May 17, 2003·Pain·Mary Elizabeth LynchJana Sawynok
Sep 23, 2003·Pain·James C EisenachRegina Curry
Feb 21, 2004·The Journal of Pain : Official Journal of the American Pain Society·James C EisenachXinhui Li
Feb 25, 2005·Anesthesia and Analgesia·Igor Kissin
Feb 25, 2005·Anesthesia and Analgesia·Cliff K-S OngBrian J Jenkins
Citations
Apr 29, 2010·Current Pain and Headache Reports·Erin F Lawson, Mark S Wallace
Aug 16, 2013·Obstetrical & Gynecological Survey·Laleh AzariShelby E Osborne
Oct 1, 2007·Neuromodulation : Journal of the International Neuromodulation Society·Timothy DeerAnne Ver Donck
Apr 1, 2008·Neuromodulation : Journal of the International Neuromodulation Society·Timothy DeerAnn Ver Donck
Aug 7, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Lu YaoMichael Garnet Irwin
Oct 24, 2007·Peptides·Richard J Bodnar
Apr 14, 2010·Anaesthesia·M D Wiles, M H Nathanson
Oct 27, 2016·Neuroscience·J Sawynok
Sep 4, 2010·Pain·Flávia Oliveira LimaThiago M Cunha
Mar 24, 2017·PloS One·Xin Jin, Weidong Mi
Oct 20, 2017·Anesthesia and Analgesia·Nebojsa Nick KnezevicTony L Yaksh
Nov 27, 2008·Anesthesiology·Ashraf S HabibUNKNOWN Adenosine Study Group
Sep 23, 2006·Expert Opinion on Investigational Drugs·Piotr Smolewski
Jun 12, 2014·Journal of Receptor and Signal Transduction Research·Tian-Biao Zhou, Zong-Pei Jiang
Sep 5, 2017·World Journal of Clinical Cases·Amlan SwainDevi Prasad Samaddar
Jun 21, 2016·Journal of Neuroscience Research·Heng YanXin Zhao