Abstract
This meta-analysis aimed to explore the efficiency of intrauterine perfusion of granulocyte colony-stimulating factor (G-CSF) on infertile women with thin endometrium. Following PRISMA protocol, we conducted a comprehensive search of academic literatures on various databases including PubMed, EMbase, and Cochrane Library. Studies published in English before July 1, 2016 were included for primary screening. Data on the thickness of endometrium, cycle cancelation rate,clinical pregnancy rate, and embryo implantation rate were extracted and analyzed, respectively. Eleven eligible studies involving 683 patients were included in this meta-analysis. Compared with control group, G-CSF perfusion could significantly improve endometrial thickness (mean difference [MD]=1.79, 95% confidence interval (CI): 0.92-2.67), clinical pregnancy rate (risk ratio [RR]=2.52, 95% CI: 1.39-4.55), and embryo implantation rate (RR=2.35, 95% CI: 1.20-4.60), while it could decrease cycle cancelation rate (RR=0.38, 95% CI: 0.25-0.58). Funnel plots revealed that there was no evidence of publication bias. The current data indicate that intrauterine perfusion of G-CSF can improve endometrial thickness, clinical pregnancy rate, and embryo implantation rate, but ...Continue Reading
References
Jan 5, 1986·Nature·S NagataH Nomura
Dec 1, 1993·Immunology Letters·T TagaA Uchida
Nov 1, 1995·European Journal of Clinical Investigation·S MakinodaS Fujimoto
Dec 1, 1995·Human Reproduction·Y W LokeT D Burrows
Dec 24, 1997·Human Reproduction·D L HockE Kemmann
Aug 4, 1998·Human Reproduction·P Sundström
Jul 27, 2000·Journal of Assisted Reproduction and Genetics·Y Y HsiehC L Chen
Nov 29, 2002·Human Reproduction·K YanagiT Nojima
Jan 30, 2003·American Journal of Hematology·David C DaleKarl Welte
Feb 6, 2003·Fertility and Sterility·Hélène Letur-Konirsch, Sylvie Delanian
Jun 12, 2003·Fertility and Sterility·Amihai BarashIrit Granot
Mar 3, 2004·Reproductive Biomedicine Online·Ri-Cheng ChianSeang-Lin Tan
May 14, 2005·Human Reproduction·A SalmassiL Mettler
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sergio RutellaGiuseppe Leone
May 27, 2006·Journal of Women's Health·Michael ZingerMichael A Thomas
Nov 1, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·César Gómez RaposoManuel González Barón
Aug 8, 2007·Fertility and Sterility·Tarek El-ToukhyPeter Braude
Sep 4, 2008·Reproductive Biology and Endocrinology : RB&E·Ahlam Al-GhamdiKhalid Awartani
Nov 27, 2009·Human Fertility : Journal of the British Fertility Society·Santanu AcharyaAdam H Balen
Aug 21, 2010·Transfusion·Laura SchlahsaConstança Figueiredo
Feb 18, 2011·Fertility and Sterility·Norbert GleicherDavid H Barad
Jul 21, 2011·Journal of Human Reproductive Sciences·Neeta SinghAshok Bhatt
Jan 31, 2012·International Journal of Immunogenetics·E Arrieta-BolañosB E Shaw
Oct 20, 2012·Human Reproduction·N GleicherD H Barad
Jan 25, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Claudia SantjohanserBettina Toth
Feb 6, 2013·The Journal of Obstetrics and Gynaecology Research·Meng-Shun ShenChii-Ruey Tzeng
May 15, 2013·Reproductive Biology and Endocrinology : RB&E·Patricia T JimenezEmily S Jungheim
Jul 6, 2013·Human Reproduction Update·C A VenetisB C Tarlatzis
Jul 26, 2013·Reproductive Sciences·Yu LiDongzi Yang
Mar 26, 2014·Human Reproduction Update·Annemieke KasiusFrank J M Broekmans
Apr 3, 2014·BioMed Research International·Michał KunickiJoanna Szczyptańska
Jun 21, 2014·Reproductive Sciences·Jing ZhaoYanping Li
Sep 25, 2014·Placenta·V A FurmentoL P Roguin
Jan 24, 2015·Personality and Mental Health·Michael BaliousisBirgit Völlm
Feb 16, 2015·Reproductive Biomedicine Online·Bin XuYanping Li
Mar 6, 2015·Journal of Reproductive Immunology·Wolfgang Würfel
Sep 5, 2015·Breast Cancer Research and Treatment·Tran DoMeghana V Trivedi
Sep 22, 2016·Journal of Obstetrics and Gynaecology of India·Vineet V MishraNilesh Goraniya
Sep 24, 2016·Reproductive Biology and Endocrinology : RB&E·J ZhaoY P Li
Citations
Jan 13, 2018·Biology of Reproduction·Xiaona LinSongying Zhang
Sep 19, 2017·American Journal of Reproductive Immunology : AJRI·Tao ZhangGil Mor
Sep 17, 2018·Archives of Gynecology and Obstetrics·Ling ZhangJing Shu
Dec 28, 2018·American Journal of Reproductive Immunology : AJRI·Tao ZhangJoanne Kwak-Kim
Jul 31, 2019·International Journal of Molecular Sciences·Andrea Olmos-OrtizVerónica Zaga-Clavellina
Mar 22, 2020·Scientific Reports·Ziya KalemTimur Gurgan
Sep 10, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Hulusi Bulent ZeynelogluUtkun Moran
Jan 1, 2021·Human Reproduction Open·Mariano MascarenhasMohan S Kamath
Mar 3, 2021·Reproductive Sciences·Hwa Seon KooYoun-Jung Kang
Sep 21, 2020·Life Sciences·Yiran XieYihua Yang
Apr 3, 2021·Scientific Reports·Hwa Seon KooYoun-Jung Kang
Apr 3, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Yuechun WangWenpei Bai
Jul 24, 2021·Stem Cell Research & Therapy·Yanling ZhangSongying Zhang
Jul 23, 2021·Molecular Reproduction and Development·Lucía de Miguel-GómezIrene Cervelló