Efficacy of intrauterine perfusion of granulocyte colony-stimulating factor (G-CSF) for Infertile women with thin endometrium: A systematic review and meta-analysis

American Journal of Reproductive Immunology : AJRI
Yiran XieYihua Yang

Abstract

This meta-analysis aimed to explore the efficiency of intrauterine perfusion of granulocyte colony-stimulating factor (G-CSF) on infertile women with thin endometrium. Following PRISMA protocol, we conducted a comprehensive search of academic literatures on various databases including PubMed, EMbase, and Cochrane Library. Studies published in English before July 1, 2016 were included for primary screening. Data on the thickness of endometrium, cycle cancelation rate,clinical pregnancy rate, and embryo implantation rate were extracted and analyzed, respectively. Eleven eligible studies involving 683 patients were included in this meta-analysis. Compared with control group, G-CSF perfusion could significantly improve endometrial thickness (mean difference [MD]=1.79, 95% confidence interval (CI): 0.92-2.67), clinical pregnancy rate (risk ratio [RR]=2.52, 95% CI: 1.39-4.55), and embryo implantation rate (RR=2.35, 95% CI: 1.20-4.60), while it could decrease cycle cancelation rate (RR=0.38, 95% CI: 0.25-0.58). Funnel plots revealed that there was no evidence of publication bias. The current data indicate that intrauterine perfusion of G-CSF can improve endometrial thickness, clinical pregnancy rate, and embryo implantation rate, but ...Continue Reading

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Citations

Sep 19, 2017·American Journal of Reproductive Immunology : AJRI·Tao ZhangGil Mor
Dec 28, 2018·American Journal of Reproductive Immunology : AJRI·Tao ZhangJoanne Kwak-Kim
Jul 31, 2019·International Journal of Molecular Sciences·Andrea Olmos-OrtizVerónica Zaga-Clavellina
Mar 22, 2020·Scientific Reports·Ziya KalemTimur Gurgan
Sep 10, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Hulusi Bulent ZeynelogluUtkun Moran
Apr 3, 2021·Scientific Reports·Hwa Seon KooYoun-Jung Kang
Apr 3, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Yuechun WangWenpei Bai

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