PMID: 7547231Oct 1, 1995Paper

Efficacy of intravenous delta-aminolaevulinic acid photodynamic therapy on rabbit papillomas

British Journal of Cancer
L A LofgrenB M Steinberg

Abstract

Endogenously induced protoporphyrin IX (PPIX), a metabolite of delta-aminolaevulinic acid (ALA), has been evaluated as a photosensitising agent for destruction of papillomas in cottontail rabbit papillomavirus-infected Dutch belted and New Zealand rabbits. Three factors were evaluated: (1) relative retention ratio of drug in normal tissue, papilloma and plasma over time; (2) tissue tolerance to treatment factors; and (3) efficacy of treatment protocol. Three drug doses of ALA were examined: 50, 100 and 200 mg kg-1. Actual PPIX concentrations in tissue and plasma were determined spectrophotofluorometrically. The optimal treatment time occurred 3-6 h post ALA injection. The highest PPIX concentration ratio between papilloma and normal skin was 6:1. Different light doses were investigated, using an injection to exposure interval of 3 h and an irradiance of 100 mW cm-2 at a wavelength of 630 nm. Efficacy without risk of significant damage to normal skin was obtained using 100-200 mg kg-1 ALA and 40-60 J cm-2. A long-term (3 months) cure rate of 82% was obtained with a single treatment, provided that papilloma depth did not exceed 8 mm, volume was not more than 1000 mm3 and the plasma concentration of PPIX immediately before exposur...Continue Reading

Citations

Nov 25, 2003·The British Journal of Dermatology·I M StefanakiA D Tosca
Mar 19, 2008·Expert Opinion on Pharmacotherapy·Jason Dunn, Laurence Lovat
Sep 30, 2009·The Journal of Dermatology·Akiko OhtsukiShigaku Ikeda
Mar 17, 1999·International Journal of Cancer. Journal International Du Cancer·P HillemannsH Hepp
Feb 1, 1997·Photochemistry and Photobiology·Q PengJ M Nesland
Dec 11, 2013·SpringerPlus·Junko TakahashiHitoshi Iwahashi
Sep 24, 1998·Journal of Photochemistry and Photobiology. B, Biology·J van den BoogertH W Tilanus

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