PMID: 9549649Apr 29, 1998Paper

Efficacy of intravenous granisetron in suppressing the bradycardia and hypotension associated with a rabbit model of the Bezold-Jarisch reflex

Journal of Clinical Pharmacology
C M WhiteM Bazunga

Abstract

This study investigated whether granisetron, a 5-HT3 receptor antagonist, can alter the Bezold-Jarisch reflex (i.e., hypotension and inappropriate heart rate slowing). A hemorrhagic rabbit model that has been shown to induce the Bezold-Jarisch reflex was used. In 11 rabbits (3.8 kg), catheters were placed in the carotid arteries one day before experimental hemorrhage. On the day of the study, the rabbits were given intravenous granisetron (50 micrograms/kg) or an equal volume of saline. Five minutes after administration of granisetron or saline, hemorrhage was induced by continuous blood withdrawal at 5 mL/min and blood pressure (BP) and heart rates were obtained at frequent intervals until systolic BP declined to 80 mmHg. Six rabbits received saline and five granisetron. An average of 77.6 mL +/- 16.4 mL of blood was removed in the group receiving granisetron (compared with 56.5 mL +/- 13.1 mL for the saline group) before achieving the target systolic BP of 80 mmHg. The group receiving granisetron demonstrated the same ability to increase their heart rate from baseline as the saline group. However, the granisetron group had a final heart rate that was closer to their maximal heart rate than the saline group. In this animal mod...Continue Reading

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Citations

Mar 11, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Robert M Martinek
Sep 1, 2016·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Nabih I El Khouly, Ashraf M Meligy
Mar 30, 2002·The Journal of International Medical Research·S CanbazE Duran
Dec 21, 2000·Journal of Clinical Pharmacy and Therapeutics·P ReddyP D Thompson
Mar 11, 2000·Pharmacotherapy·C M White, J P Tsikouris

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