Efficacy of intravenous immunoglobulin in the treatment of persistent BK viremia and BK virus nephropathy in renal transplant recipients

Transplantation Proceedings
D VuD Min

Abstract

BK virus-associated nephropathy (BKVN) can cause clinically significant viral infection in renal transplant recipients, leading to allograft dysfunction and loss. The usual management of BKVN involves the reduction of immunosuppression and the addition of leflunomide, quinolones, and cidofovir, but the rate of graft loss remains high. The aim of this study was to assess the impact of treatment with intravenous human immunoglobulin (IVIG) on the outcome of BKVN in renal transplant recipients. Upon diagnosis of BKVN, patients remained on anti-polyomavirus treatment, consisting of the reduction of immunosuppression and the use of leflunomide therapy. Treatment with IVIG was given only to patients who did not respond to 8 weeks of the adjustment of immunosuppression and leflunomide. All 30 patients had persistent BKV viremia and BKVN with their mean BK viral loads higher than the baseline (range, 15,000-2 million copies/mL). Mean peak BK load was 205,314 copies/mL compared with 697 copies/mL after 1 year of follow-up. Twenty-seven patients (90%) had a positive response in clearing viremia. The actuarial patient and graft survival rates after 12 months were 100% and 96.7%, respectively. IVIG administration appeared to be safe and ef...Continue Reading

References

Jul 26, 2002·Journal of the American Society of Nephrology : JASN·Emilio RamosMatthew R Weir
Mar 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Pradeep V KadambiAjit P Limaye
Oct 3, 2003·The Lancet Infectious Diseases·Hans H Hirsch, Jürg Steiger
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Uwe PögeRainer P Woitas
Oct 11, 2005·Transplantation Proceedings·M R N NampooryW Al-Nakib
Apr 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H M WadeiM D Griffin
Oct 3, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F GinevriP Comoli
Mar 29, 2008·Annual Review of Immunology·Falk Nimmerjahn, Jeffrey V Ravetch
Jul 25, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Andrew S WeissAlexander C Wiseman
Jul 9, 2009·Transplantation·Stanley C JordanAshley A Vo
Nov 4, 2009·Clinical and Experimental Immunology·A DurandyR Rieben
Jan 9, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K L HardingerD C Brennan
Jun 24, 2010·Transplantation·Parmjeet S RandhawaYuchen Huang
Dec 1, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S SchaubM Mayr
Aug 13, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Gregor BartelGeorg A Böhmig

❮ Previous
Next ❯

Citations

Jan 19, 2016·Nephrology·Jagadish S Jamboti
Oct 25, 2016·Seminars in Nephrology·Jennifer Trofe-Clark, Deirdre Sawinski
Oct 8, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Aurore BarthélemyBruno Hurault de Ligny
Apr 14, 2017·Transplantation Direct·Kathy KableBrian John Nankivell
May 26, 2017·Current Opinion in Organ Transplantation·Stephanie G YiKeri E Lunsford
May 17, 2018·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Karel KrejciJosef Zadrazil
Sep 30, 2016·World Journal of Transplantation·Darlene VigilAntonios H Tzamaloukas
Jan 10, 2018·World Journal of Transplantation·Jacob Rw ScaddenRichard Borrows
Sep 4, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Steven GabardiAnil Chandraker
Mar 17, 2017·Clinical Microbiology Reviews·George R AmbalathingalRajiv Khanna
Dec 10, 2017·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Andrew D SanteusanioJudy Eun
Jan 9, 2019·Kidney Research and Clinical Practice·Jakapat VanichananKamonwan Jutivorakool
Mar 13, 2019·Clinical Transplantation·Hans H HirschUNKNOWN AST Infectious Diseases Community of Practice
Mar 26, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Ankur ShahJonathan J Hogan
Oct 1, 2019·Current Opinion in Infectious Diseases·Amandeep KaurHans H Hirsch
Jan 1, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Suman Krishna KotlaRebecca Rojas
Apr 24, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Jungyeon MoonDavid I Min
Aug 3, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ilies BenotmaneSophie Caillard
Oct 25, 2016·Transplantation·Caroline LamarcheJean-Sébastien Delisle
Nov 5, 2015·Current Opinion in Organ Transplantation·Fasika M TedlaAmarpali Brar
Mar 5, 2019·F1000Research·Abraham Cohen-BucayJean M Francis
Aug 22, 2020·International Journal of Nephrology and Renovascular Disease·Rajeev Sharma, Mareena Zachariah
Apr 14, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Jack AguilarJon Kobashigawa
Jun 20, 2020·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Ahmed SalehAhmed Halawa
Feb 3, 2021·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·John Fredy Nieto-RíosLina María Serna-Higuita
Oct 30, 2020·Therapeutics and Clinical Risk Management·Soichi MatsumuraRyoichi Imamura
Feb 6, 2020·Microbial Pathogenesis·Brandon Dow ChanWilliam Chi-Shing Tai
Jun 12, 2020·The Journal of Infection·Anastasia SaadeUNKNOWN Infectious Disease Working party of EBMT
Oct 12, 2016·Microbiology Spectrum·Linda Cook
Apr 20, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Bettina NaefThomas Schachtner
Aug 3, 2021·Frontiers in Medicine·Sergi CodinaJosep M Cruzado

❮ Previous
Next ❯

Related Concepts

Related Feeds

BK Virus Infection

BK virus infection is a significant complication of modern immunosuppression used in kidney transplantation. Discover the latest research on BK virus infection here.