Efficacy of intravesical mitomycin C in the treatment of superficial transitional cell carcinoma of the urinary bladder

Journal of Surgical Oncology
A PavlotskyY Horn

Abstract

We treated 47 patients with recurrent transitional cell carcinoma of the bladder with intravesical chemotherapy. Twenty milligrams of mitomycin C per treatment was introduced 7 days after transurethral resection (TUR) or diagnostic cystoscopy, and was repeated at 2-week intervals for five times followed again by cystoscopy. Two more similar courses were administered for a total of 36 weeks. Clinical data revealed no toxicity-related symptoms. Cystoscopic follow-up showed a gradual decline in the presence of tumor to a complete response rate of 87.1% at 36 weeks. Thirteen patients who were previously treatment failures with other drugs responded to mitomycin C.

References

Aug 1, 1975·The Journal of Urology·T MishinaY Mori
Dec 1, 1983·British Journal of Urology·G S HarrisonP H Smith
Dec 1, 1983·The Journal of Urology·N M HeneyI R Hawkins
May 1, 1981·The Journal of Urology·M S SolowayP Finebaum
Sep 16, 1961·Lancet·H C JONES, J SWINNEY

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Citations

Oct 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Renzo ColomboMichele Pavone-Macaluso

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