Efficacy of isotonic nasal wash (seawater) in the treatment and prevention of rhinitis in children

Archives of Otolaryngology--head & Neck Surgery
Ivo SlapakPavel Horník

Abstract

To evaluate the potential of nasal isotonic saline application to prevent reappearance of cold and flu in children during the winter. Prospective, multicenter, parallel-group, open, and randomized comparison. Eight pediatric outpatient clinics. A total of 401 children (aged 6-10 years) with uncomplicated cold or flu. We randomly assigned patients to 2 treatment groups, one with just standard medication, the other with nasal wash with a modified seawater solution (Physiomer) plus standard medication, and observed them for 12 weeks. The primary efficacy end points were nasal symptoms resolution during acute illness (visits 1 and 2). We also looked for reappearance of cold or flu, consumption of medication, complications, days off school, and reported days of illness during the following weeks when preventive potential was evaluated (visits 3 and 4). At visit 2, patients in the saline group achieved primary end points (measured on a 4-point numeric scale on which 1 indicated no symptoms and 4, severe symptoms) in the parameters nasal secretion and obstruction (mean scores vs nonsaline group, 1.79 vs 2.10 and 1.25 vs 1.58, respectively) (P < .05 for both). During the prevention phase (at visit 3, 8 weeks after study entry) patients...Continue Reading

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