Efficacy of L-carnitine on ribavirin-induced hemolytic anemia in patients with hepatitis C virus infection

Clinical and Molecular Hepatology
Shinya SatoHitoshi Yoshiji

Abstract

L-carnitine not only alleviates hyperammonemia and reduces muscle cramps in patients with liver cirrhosis, but also improves anemia in patients with chronic hepatitis and renal dysfunction. This study prospectively evaluated the preventative efficacy of L-carnitine supplementation against hemolytic anemia during antiviral treatment using ribavirin in patients with hepatitis C virus (HCV)-related chronic liver disease. A total of 41 patients with chronic hepatitis were consecutively enrolled in this study. Group A (n=22) received sofosbuvir plus ribavirin for 3 months, whereas group B (n=19) was treated with sofosbuvir, ribavirin, and L-carnitine. Hemoglobin concentration changes, the effects of antiviral treatment, and the health status of patients were analyzed using short form-8 questionnaires. A significantly smaller decrease in hemoglobin concentration was observed in group B compared to group A at every time point. Moreover, the prescribed dose intensity of ribavirin in group B was higher than that of group A, resulting in a higher ratio of sustained virological response (SVR) 24 in group B compared with group A. The physical function of patients in group B was also significantly improved compared to group A at the end of ...Continue Reading

References

Jul 1, 1986·Preventive Medicine·B S Kendler
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L De FranceschiR Corrocher
Mar 5, 2004·Annals of Internal Medicine·Stephanos J HadziyannisUNKNOWN PEGASYS International Study Group
Jan 8, 2005·Aging Clinical and Experimental Research·V Nimet Izgüt-UysalNarin Derin
Oct 18, 2005·Acta Haematologica·A El-BeshlawyA Taher
Dec 16, 2006·Current Medicinal Chemistry·Stefan RussmannGiuseppe Palasciano
Oct 24, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Eric D WeinhandlBrian J G Pereira
Dec 18, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Thilakavathy ThangasamyPanneerselvam Chinnakkanu
Sep 12, 2008·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Yasuharu TokudaTsuguya Fukui
Jan 14, 2010·Cell Biology and Toxicology·Joanna Saluk-JuszczakEdward Bald
Feb 16, 2012·Current Opinion in Gastroenterology·Mariano Malaguarnera
Dec 12, 2012·Journal of the American Society of Nephrology : JASN·Eric G Neilson
Jan 4, 2013·The New England Journal of Medicine·Edward J GaneM Michelle Berrey
Jan 11, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Tarik Asselah, Patrick Marcellin
Aug 3, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael W FriedMaria Beumont-Mauviel
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Nov 1, 2013·Journal of Clinical Gastroenterology·Valérie Martel-LaferrièreDouglas T Dieterich
Dec 17, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Hiroyuki NakanishiNamiki Izumi
Jun 18, 2015·Journal of Viral Hepatitis·J A GutierrezF Poordad
Nov 17, 2015·The New England Journal of Medicine·Michael P CurryUNKNOWN ASTRAL-4 Investigators
Apr 21, 2016·Journal of Medical Virology·Lan S WangIra M Jacobson
Jun 3, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Makoto ShirakiKazuhiko Koike
Sep 20, 2016·Journal of Hepatology·Adriaan J van der Meer, Marina Berenguer
Sep 25, 2016·Journal of Medical Virology·Yoko TsukudaNaoya Sakamoto
May 13, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Edward J GaneUNKNOWN GS-US-342-1553 Investigators

❮ Previous
Next ❯

Software Mentioned

CONSORT

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.