PMID: 8604928Dec 1, 1995Paper

Efficacy of leukocyte filters in the bypass circuit for infants undergoing cardiac operations

The Annals of Thoracic Surgery
R Englander, M G Cardarelli

Abstract

Leukocyte filters have been used in cardiopulmonary bypass circuits to decrease potentially deleterious consequences of white blood cell product release in adults undergoing cardiac operations. Studies in animal models have also demonstrated benefits of white blood cell depletion during cardiopulmonary bypass. We sought to examine the efficacy of a leukocyte filter placed in the bypass circuit of infants undergoing operation for correction of congenital heart disease. We conducted a retrospective study of infants undergoing correction of congenital heart defects (all had left-to-right shunts) between July 1993 and May 1994. Six infants (group I) had a Leukoguard-3 leukocyte filter (Pall Biomedical Products) placed in the arterial limb of the bypass circuit, and 6 infants (group II) had no filter. We analyzed for differences between groups in intraoperative variables (total pump time, aortic cross-clamp time, deep hypothermic cardiac arrest time, and time for rewarming), postoperative clinical variables (fever in the first 24 hours, days of mechanical ventilation, length of intensive care unit stay, and total hospital stay) and laboratory variables (change in white blood cell and platelet counts preoperatively to postoperatively...Continue Reading

References

Feb 1, 1992·The Annals of Thoracic Surgery·G G DaviesN J Melling
Nov 1, 1994·The Annals of Thoracic Surgery·S M Coleman, L Demastrice
Jan 1, 1993·The Annals of Thoracic Surgery·I C WilsonT J Gardner
Feb 1, 1993·The Annals of Thoracic Surgery·J ButlerS Westaby

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Citations

Jan 24, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Oliver WarrenThanos Athanasiou
Aug 14, 2002·The Annals of Thoracic Surgery·Augustine T M TangSunil K Ohri
May 9, 2003·The Annals of Thoracic Surgery·Torsten DoenstFriedhelm Beyersdorf
Apr 20, 2001·Acta Anaesthesiologica Scandinavica·A SahlmanO J Rämö
Mar 16, 2002·Transfusion·Dean FergussonStanley H Shapiro
Sep 22, 2001·Perfusion·G MatheisA Moritz

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