Efficacy of lifestyle changes in subjects with non-alcoholic liver steatosis and metabolic syndrome may be improved with an antioxidant nutraceutical: a controlled clinical study

Drugs in R&D
Gianpaolo SorrentinoGiorgio De Stefano

Abstract

The prevalence of liver steatosis is particularly high in subjects with signs of the metabolic syndrome, and current therapeutic guidelines mostly rely on lifestyle changes alone, which rarely achieve significant objective improvements. In the present study, we evaluated the possibility of monitoring objective improvements in these subjects, before and after a dietary regimen. Overall, 78 subjects with metabolic syndrome and ultrasound confirmation of liver steatosis were included in an open, controlled study; all of these subjects were treated for 90 days with the standard regimen of diet and exercise. One group of 43 subjects (Group A) also received a Eurosil 85(®)-based nutraceutical (silymarin + vitamin E) as a dietary adjunct, whereas the remaining 35 subjects (Group B) represented the control group. Changes from baseline values were recorded in biometric, biochemical, and ultrasound data. For assessments and monitoring of liver steatosis, two indexes were utilised-Hepatic Steatosis Index (HSI) and Lipid Accumulation Product (LAP) index. The absolute changes from baseline were significantly higher in Group A in biometric parameters (reduction of abdominal circumference, Body Mass Index, ultrasound measurement of right live...Continue Reading

References

Jan 22, 2000·Annals of Internal Medicine·S BellentaniC Tiribelli
Jul 27, 2001·Diabetes·G MarchesiniN Melchionda
May 10, 2002·Journal of Gastroenterology and Hepatology·Paul Angulo, Keith D Lindor
Aug 29, 2002·Gastroenterology·Sherif SaadehMichael J Sheridan
Oct 19, 2004·European Journal of Gastroenterology & Hepatology·Stefano BellentaniClaudio Tiribelli
Jul 27, 2007·Journal of Medicinal Food·Soo-Hyun KimSeung-Shi Ham
Aug 10, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giorgio BedogniStefano Bellentani
Sep 22, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Jeong-Hoon LeeHyo-Suk Lee
Oct 15, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kittichai PromratRena R Wing
Oct 21, 2009·Journal of Clinical Pharmacology·Roy L HawkeUNKNOWN SyNCH Trial Group
Jan 19, 2010·Annual Review of Pathology·Dina G TiniakosElizabeth M Brunt
Apr 30, 2010·The New England Journal of Medicine·Arun J SanyalUNKNOWN NASH CRN
Aug 27, 2010·BMC Gastroenterology·Giorgio BedogniClaudio Tiribelli
Oct 1, 2010·The New England Journal of Medicine·Giovanni TargherEnzo Bonora
Jun 28, 2011·Science·Jonathan C CohenHelen H Hobbs
Dec 4, 2012·Journal of Hepatology·Elena CentisGiulio Marchesini
Feb 18, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Francesca M TrovatoGuglielmo M Trovato
Oct 1, 2014·Alimentary Pharmacology & Therapeutics·L FedchukUNKNOWN LIDO Study Group
Dec 11, 2014·World Journal of Gastroenterology : WJG·Ludovico AbenavoliStefano Bellentani
Dec 18, 2014·Reviews on Recent Clinical Trials·Mario MasaroneMarcello Persico

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Citations

Oct 6, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Federico SalomoneShira Zelber-Sagi
May 24, 2016·Journal of Medicinal Food·Rosa María Piña-ZentellaMinerva Ramos-Gomez
May 8, 2018·Journal of the Science of Food and Agriculture·Maryam VahabzadehGholamreza Karimi
Jul 24, 2018·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Rocío AllerDaniel de Luis
Apr 3, 2019·International Journal of Molecular Sciences·Almudena Pérez-SánchezJavier A Menendez
Nov 8, 2017·British Journal of Cancer·Stephanie MarkovinaPerry W Grigsby
Aug 9, 2017·World Journal of Gastroenterology : WJG·Camila Ribeiro de AvelarLucivalda Pereira Magalhães de Oliveira
Feb 18, 2020·Advances in Therapy·Anton Gillessen, Hartmut H-J Schmidt
Feb 8, 2016·British Journal of Clinical Pharmacology·Maria Del BenFrancesco Angelico
Nov 4, 2016·Nature Reviews. Gastroenterology & Hepatology·Stephanie R WesolowskiJacob E Friedman
Sep 2, 2017·Journal of the Science of Food and Agriculture·Arunaksharan NarayanankuttyAchuthan C Raghavamenon
Jan 15, 2021·Minerva gastroenterologica e dietologica·Beniamino PalmieriMaria VadalÀ

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Methods Mentioned

BETA
imaging techniques
biopsy

Software Mentioned

SAS

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