Efficacy of locally-delivered 1% metformin gel in the treatment of intrabony defects in patients with chronic periodontitis: a randomized, controlled clinical trial

Journal of Investigative and Clinical Dentistry
A R PradeepArjun Raju

Abstract

Metformin (MF), used for the treatment of type 2 diabetes mellitus, has shown to possess properties favoring osteoblastic proliferation. The present study was designed to investigate the effectiveness of MF 1% gel as an adjunct to scaling and root planing in the treatment of intrabony defects in patients with chronic periodontitis. The study comprised 65 individuals divided into two groups: 1% MF with SRP and placebo gel with SRP. Clinical parameters were evaluated at baseline, 3 months, and 6 months; they included plaque index, modified sulcus bleeding index, probing depth (PD), and clinical attachment level (CAL). Intrabony defect depth (IBD) was evaluated at the end of 6 months using computer-aided software. The mean PD reduction, CAL gain, and IBD depth reduction were found to be greater in the MF group than in the placebo group at all visits. The percentage of defect depth reduction was significantly greater in the MF group (26.8 ± 5.52%) than in the placebo sites (4.79 ± 2.30%, P < 0.001). One percent MF was found to significantly improve clinical and radiographic parameters in intrabony defects in patients with chronic periodontitis.

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Citations

May 12, 2017·Journal of Tissue Engineering and Regenerative Medicine·Ping WangAbraham Schneider
Nov 24, 2018·Diabetes/metabolism Research and Reviews·Evangelia KalaitzoglouKathryn M Thrailkill
Nov 23, 2018·Drug Delivery and Translational Research·Suping WangHockin H K Xu
Jul 6, 2017·Journal of Applied Oral Science : Revista FOB·Bernardo Carvalho DutraFernando Oliveira Costa
Jul 6, 2017·Journal of Applied Oral Science : Revista FOB·Anuj SharmaAvani Raju Pradeep
Oct 18, 2018·Clinical Oral Investigations·Alessandra Cardoso NicoliniJuliano Cavagni
Jul 1, 2020·International Journal of Biological Macromolecules·Elaheh FakhriHossein Samadi Kafil
Jun 13, 2020·International Journal of Pharmaceutics·Catherine PetitOlivier Huck
Oct 6, 2021·JDR Clinical and Translational Research·J C GunsolleyE Ioannidou

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