PMID: 9160033May 1, 1997Paper

Efficacy of lodoxamide eye drops on mast cells and eosinophils after allergen challenge in allergic conjunctivitis

Ophthalmology
S BoniniM G Bucci

Abstract

The purpose of the study is to evaluate in a double-blind, randomized study the efficacy of lodoxamide tromethamine 0.1% versus placebo. Signs and symptoms, tear tryptase, and tear fluid cytology were evaluated in 20 asymptomatic subjects with allergic conjunctivitis. The study included three allergen challenges in skin test-positive patients. At the first visit, a threshold dose of allergen was established. At the second visit, a bilateral ocular challenge was performed without pretreatment. At the third visit, either lodoxamide or placebo eye drops were used for 1 week before ocular challenge. Lodoxamide significantly reduced tryptase levels (P < 0.01), neutrophils (P < 0.04), and eosinophils (P < 0.01) in the tear fluid and significantly inhibited ocular itching (P < 0.02) when compared with that of placebo. Lodoxamide is effective in reducing tryptase levels and the recruitment of inflammatory cells in the tear fluid after allergen challenge.

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Citations

Aug 5, 2000·The Journal of Pathology·B LazarusK R Knight
Mar 15, 2002·Current Allergy and Asthma Reports·M Friedlaender
Jul 31, 2013·Experimental Eye Research·Andrea Leonardi
Jun 14, 2003·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Christian Schoch
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Dec 11, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Katrina L Schmid, Leisa M Schmid
Jan 30, 1999·The British Journal of Ophthalmology·J I McGillA Bacon
Sep 21, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Flavio MantelliStefano Bonini
Aug 20, 2014·Ophthalmology and Therapy·Andrea Leonardi
Feb 13, 2003·Current Opinion in Allergy and Clinical Immunology·Mitchell H Friedlaender
Feb 13, 2003·Current Opinion in Allergy and Clinical Immunology·Leonard BieloryTheoharis Theoharides
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Feb 20, 2008·Immunology and Allergy Clinics of North America·Leonard Bielory
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Jan 21, 2014·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Pakit VichyanondAndrea Leonardi
Jan 17, 2007·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Adil Kiliç, Bülent Gürler
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Mar 24, 2010·Expert Opinion on Pharmacotherapy·Andrea Leonardi, Luigi Quintieri
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Mar 17, 2020·Oman Journal of Ophthalmology·Dora Hamad AlHarkan
Sep 2, 2020·Computational and Structural Biotechnology Journal·Qizhang LiSen Liu

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