PMID: 7546987Aug 1, 1995Paper

Efficacy of long-term anticoagulant treatment in subgroups of patients after myocardial infarction

British Heart Journal
P F van BergenA Hofman

Abstract

To investigate the efficacy of long term oral anticoagulant treatment in subgroups of patients after myocardial infarction. Analysis of the effect of anticoagulant treatment in subgroups of hospital survivors of myocardial infarction based upon age, gender, history of hypertension, previous myocardial infarction, smoking habits, diabetes mellitus, Killip class, anterior location of infarction, thrombolytic therapy, and use of beta blockers. Participants of a multicentre, randomised, double blind, placebo controlled trial that assessed the effect of oral anticoagulant treatment on mortality as well as cerebrovascular and cardiovascular morbidity in 3404 hospital survivors of acute myocardial infarction. The effect of anticoagulant treatment on recurrent myocardial infarction, cerebrovascular events, and vascular events (the composite endpoint of reinfarction, cerebrovascular event, and vascular death). Long term anticoagulant treatment was associated with a reduction in mortality of 10% (95% confidence interval -11% to 27%), recurrent myocardial infarction of 53% (41% to 62%), cerebrovascular events of 40% (10% to 60%) and vascular events of 35% (24% to 45%). Treatment effect with respect to recurrent myocardial infarction was c...Continue Reading

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Citations

May 16, 2007·Heart·Menno E van der ElstAnthonius de Boer
Feb 23, 1999·Chest·T BorrowmanJ W Mason
Oct 2, 2003·The Annals of Pharmacotherapy·Menno E van der ElstAnthonius de Boer

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