Efficacy of Long-Term Oral Vitamin B12 Supplementation after Total Gastrectomy: Results from a Prospective Study

GE Portuguese Journal of Gastroenterology
Joana MoleiroAntónio Dias Pereira

Abstract

Vitamin B12 (VB12) deficiency is a common complication after total gastrectomy which may be associated with megaloblastic anemia and potentially irreversible neurologic symptoms. Intramuscular supplementation of VB12 has been considered the standard treatment, although it is associated with high costs and patient discomfort. We performed a prospective uncontrolled study (ACTRN12614000107628) in order to evaluate the clinical and laboratory efficacy of long-term oral VB12 supplementation in patients submitted to total gastrectomy. All patients received daily oral VB12 (1 mg/day) and were evaluated every 3 months (clinical and laboratory evaluation: hemoglobin, VB12, total iron, ferritin, and folate). A total of 26 patients were included with a mean age of 64 years (29-79). Patients were included with a mean period of 65 months (3-309) after total gastrectomy. At inclusion time, 17/26 patients were under intramuscular VB12, and 9 had not started supplementation yet. There were normal serum VB12 levels in 25/26 patients (mean VB12 serum levels: 657 pg/mL). The mean follow-up period was 20 (8.5-28) months. During follow-up, all patients had normal VB12 levels and there was no need for intramuscular supplementation. The patient with...Continue Reading

Citations

Feb 24, 2019·QJM : Monthly Journal of the Association of Physicians·E AndrèsT Vogel
Jan 12, 2019·Drug Delivery and Translational Research·Merav Jacobson BenskyShachaf Shiber
Feb 15, 2020·Expert Opinion on Pharmacotherapy·Mariana Hollanda Martins Da RochaJoel Faintuch
Jun 14, 2019·GE Portuguese Journal of Gastroenterology·Jean-Pierre RothenIsabelle Arnet

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