Efficacy of lotilaner (Credelio™), a novel oral isoxazoline against naturally occurring mange mite infestations in dogs caused by Demodex spp

Parasites & Vectors
Daniel E SnyderJulian Liebenberg

Abstract

The oral systemic efficacy of lotilaner (Credelio™, Elanco) was evaluated against Demodex spp. in naturally infested dogs with generalized demodicosis. In this study, 10 dogs with clinical signs of generalized demodicosis and positive for Demodex spp. mites based on skin scrapings were assigned to a single group orally treated with lotilaner (minimum dose of 20 mg/kg) on Days 0, 28 and 56. For lotilaner-treated dogs, pre-treatment mite counts based on skin scrapings performed at five different sites were reduced by > 99.9% (P < 0.0001) up to 56 days after the first and second monthly doses. No live mites were detected after Day 56 out to and including Day 84 post-treatment for 100% efficacy of each dog's Demodex mite infestation. Nine of 10 dogs were 100% mite-free from Day 28 (first evaluation) through Day 84 (end of study) and live mites were only found once on one dog (Day 56) following treatment with lotilaner. All dogs in the lotilaner-treated group showed marked improvement in the clinical signs of demodicosis and there were no drug associated adverse events. A marked improvement in hair re-growth was observed in all the dogs from 6 weeks following initiation of treatment. In this study lotilaner administered at a minimum...Continue Reading

References

Nov 24, 1999·The Veterinary Clinics of North America. Small Animal Practice·M Paradis
Jun 7, 2000·Australian Veterinary Journal·M Shipstone
Feb 15, 2012·Veterinary Dermatology·Ralf S MuellerMichael A Shipstone
Mar 3, 2012·The Veterinary Clinics of North America. Small Animal Practice·Valentina M Merola, Paul A Eubig

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Citations

Jan 9, 2019·BMC Veterinary Research·Roberta PeregoDaniela Proverbio
Aug 15, 2019·The Veterinary Record·Lisa PinsenschaumRalf S Mueller
Apr 16, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·R FoleyF Powell
May 28, 2020·Journal of the American Veterinary Medical Association·Xueying ZhouWalter H Hsu
Sep 17, 2020·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Rita de Cássia da Silva Machado NevesAna Maria Reis Ferreira
Mar 19, 2021·Journal of Veterinary Pharmacology and Therapeutics·Xueying ZhouWalter H Hsu

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Methods Mentioned

BETA
scrapings
biopsies
sedation
biopsy
scraping

Software Mentioned

SAS

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