Efficacy of low-dose bepridil for prevention of ventricular fibrillation in patients with Brugada syndrome with and without SCN5A mutation

Journal of Cardiovascular Pharmacology
Masato MurakamiHiroshi Ito

Abstract

It has been reported that bepridil prevents ventricular fibrillation (VF) in patients with Brugada syndrome, but the comparative efficacy with and without mutation in the SCN5A gene has not been elucidated. The purpose of this study was to assess the efficacy of low-dose bepridil (100 mg/day) for VF prevention in patients with Brugada syndrome with and without SCN5A mutation. Among 130 patients with Brugada-type electrocardiogram (ECG), low-dose bepridil was administered to seven patients because of repetitive VF episodes, including three with and four without SCN5A mutation. Preventive effect for VF recurrence and changes of the ECG and the signal-averaged ECG were evaluated. Frequencies of VF episodes were reduced after treatment with low-dose bepridil in all three patients with the SCN5A mutation (before: 0.33 versus after: 0.02 episodes/month, P < 0.01), but not in all four patients without the SCN5A mutation (before: 0.43 versus after: 2.94 episodes/month, P = nonsignificant). Levels of ST-segment elevation at J points and duration of low-amplitude signals less than 40 µV in the terminal filtered QRS complex (LAS40) in signal-averaged ECG were improved exclusively in patients with the SCN5A mutation. Treatment with bepridi...Continue Reading

References

Oct 5, 2001·Pacing and Clinical Electrophysiology : PACE·M AlingsA Wilde
Jun 27, 2002·Journal of the American College of Cardiology·Satoshi NagaseTohru Ohe
Jun 27, 2002·Journal of the American College of Cardiology·Charles Antzelevitch
May 18, 2004·Journal of the American College of Cardiology·Jean-Sylvain HermidaAntoine Leenhardt
Sep 24, 2004·Circulation·Bernard BelhassenSami Viskin
Jan 3, 2006·Journal of Electrocardiology·Hiroshi WatanabeYoshifusa Aizawa
Jan 18, 2006·Internal Medicine·Wataru Shimizu
Jun 9, 2006·European Heart Journal·Atsuyuki WatanabeTohru Ohe
Jun 9, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Takeshi OhgoWataru Shimizu
Jul 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Kohei MiyajiTohru Ohe
Sep 25, 2007·Heart·Lisa K Hornberger, David J Sahn
Oct 22, 2008·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Daiji MiuraTohru Ohe
Jan 6, 2009·Circulation. Arrhythmia and Electrophysiology·Eva DelpónCharles Antzelevitch
Nov 11, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hiroshi MoritaJiashin Wu

❮ Previous
Next ❯

Citations

Jul 9, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Sonoko AshinoAtsushi Hirayama
Jul 18, 2014·Internal Medicine·Kengo Fukushima Kusano
Mar 19, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Yoshiyasu AizawaKeiichi Fukuda
Dec 17, 2015·Current Problems in Cardiology·Charles Antzelevitch, Bence Patocskai
Apr 15, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Charles Antzelevitch, Gan-Xin Yan
Jul 16, 2013·Journal of the American College of Cardiology·Tsukasa KamakuraWataru Shimizu
Jan 22, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Masaomi ChinushiHiroshi Furushima
Jul 18, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Charles AntzelevitchArthur A M Wilde
Oct 21, 2016·Journal of Arrhythmia·Charles AntzelevitchArthur A M Wilde
Jan 11, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Antonio CurcioCiro Indolfi
May 15, 2018·Expert Review of Cardiovascular Therapy·Mariana Argenziano, Charles Antzelevitch
May 13, 2017·Journal of Atrial Fibrillation·Yoshifusa Aizawa
Oct 17, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Tsukasa KamakuraKengo Kusano
Jun 6, 2018·Pacing and Clinical Electrophysiology : PACE·José M Di Diego, Charles Antzelevitch
Sep 16, 2014·Circulation. Arrhythmia and Electrophysiology·Yoshiaki KanekoYoshifusa Aizawa
Apr 22, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Charles AntzelevitchArthur A M Wilde
Jan 1, 2015·Expert Opinion on Orphan Drugs·Bence Patocskai, Charles Antzelevitch
Jul 4, 2018·Arrhythmia & Electrophysiology Review·Oholi Tovia BrodieBernard Belhassen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.