Efficacy of low dose gabapentin in acute herpes zoster for preventing postherpetic neuralgia: a prospective controlled study

Dermatologic Therapy
Eo G LeeMoon S Yoon

Abstract

Postherpetic neuralgia (PHN) is a sequela of herpes zoster that adversely affects quality of life seriously. The risk factors for PHN are well known but the effective interventions that reduce the incidence of PHN are less studied. The objective of this study is to evaluate the efficacy of treatment with gabapentin in patients with acute herpes zoster for preventing PHN. We performed a prospective randomized controlled study of 120 participants diagnosed with acute herpes zoster, aged 50 and over and complaining moderate to severe pain. All patients were treated with valacyclovir and acetaminophen. Half of the participants were assigned to the gabapentin group and received gabapentin 300 mg three times a day additionally. The intensity of pain at every visit and the incidence of PHN in both groups were measured. Total 52 and 49 patients in the gabapentin group and the control group, respectively, had completed 12 weeks of follow-up period. Although the incidence of PHN was higher in the control group, the difference was not statistically significant (6.1% vs. 3.8%, p = 0.67). Our results indicate that the use of low-dose gabapentin in acute herpes zoster seems not effective in the prevention of PHN.

References

Dec 1, 1986·Annals of Neurology·R K PortenoyK M Foley
Dec 10, 1998·JAMA : the Journal of the American Medical Association·M RowbothamL Magnus-Miller
Mar 15, 2003·Clinical Therapeutics·Miroslav Backonja, Robert L Glanzman
Dec 12, 2003·Clinical Therapeutics·Brett R Stacey, Robert L Glanzman
May 12, 2004·Neurology·Beth F JungRobert H Dworkin
Sep 1, 2004·The Journal of Pain : Official Journal of the American Pain Society·Paul M CoplanMichael N Oxman
Jun 3, 2005·The New England Journal of Medicine·M N OxmanUNKNOWN Shingles Prevention Study Group
Dec 5, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert H DworkinRichard J Whitley
Dec 6, 2007·Journal of the American Academy of Dermatology·Stephen K Tyring
Jan 31, 2008·The Journal of Pain : Official Journal of the American Pain Society·Anne Louise Oaklander
May 4, 2010·The Journal of Pain : Official Journal of the American Pain Society·Mélanie DroletJames A Mansi
Jun 1, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Richard J WhitleyAnne Louise Oaklander
Jul 22, 2014·Clinical and Experimental Dermatology·T Migita
Oct 16, 2014·The New England Journal of Medicine·Robert W Johnson, Andrew S C Rice
Apr 7, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Kosuke KawaiCamilo J Acosta

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Citations

Feb 2, 2017·Neuroscience Bulletin·Isaac M Chiu
Oct 14, 2017·Expert Opinion on Pharmacotherapy·John Schutzer-Weissmann, Paul Farquhar-Smith
Oct 3, 2020·Best Practice & Research. Clinical Anaesthesiology·Ivan UritsOmar Viswanath

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