Efficacy of medium chain triglyceride oil dietary supplementation in reducing seizure frequency in dogs with idiopathic epilepsy without cluster seizures: a non-blinded, prospective clinical trial.

The Veterinary Record
Jenifer MolinaHolger A Volk

Abstract

Despite appropriate antiseizure drug (ASD) treatment, around two-thirds of dogs with idiopathic epilepsy (IE) have seizures long-term and 20-30per cent of affected dogs remain poorly controlled. The current study aim is to test in a field trial the efficacy and tolerability of a commercially available diet enriched with 6.5per cent medium chain triglyceride (MCT) oil in dogs (n=21) with at least a tier 1 idiopathic epilepsy diagnosis, without cluster seizures, in 10 veterinary practices across Europe. Each dog's quality of life (QoL), ataxia, sedation and frequency and severity of seizures were recorded by owners throughout the study. The mean seizure frequency per month, averaged over the entire 84-day study, significantly (P=0.04) decreased 32per cent compared with the baseline monthly seizure frequency recorded during the month immediately before feeding the diet. Similarly, the seizure days rate (days/month) also declined (P<0.001) by 42per cent. QoL was reported as very good to excellent (>8.5/10) in 20 of the 21 dogs before starting the diet and this remained unchanged during the trial. This study demonstrates the use of a diet enriched with MCTs as an adjunct to ASD treatment may have some antiseizure properties for dogs...Continue Reading

References

Jun 1, 1985·Journal of Veterinary Pharmacology and Therapeutics·D Schwartz-PorscheH H Frey
Jan 1, 1971·European Neurology·W H Oldendorf
Jan 1, 1983·Neurobiology of Aging·E D LondonS I Rapoport
Sep 1, 1993·Journal of Veterinary Internal Medicine·M Podell, W R Fenner
Jun 30, 2006·Annals of Neurology·Kristopher J BoughRaymond J Dingledine
Jan 24, 2007·Epilepsia·Kristopher J Bough, Jong M Rho
May 6, 2008·Lancet Neurology·Elizabeth G NealJ Helen Cross
Dec 17, 2008·Epilepsia·Jong M Rho, Raman Sankar
Nov 17, 2009·Journal of Veterinary Internal Medicine·K R MuñanaE E Patterson
Feb 10, 2010·The British Journal of Nutrition·Yuanlong PanNorton W Milgram
May 3, 2011·Epilepsy & Behavior : E&B·Nadia ShihabHolger A Volk
Nov 28, 2012·Neuropharmacology·Pishan ChangRobin S B Williams
Sep 28, 2013·Topics in Companion Animal Medicine·Christopher L Mariani
Sep 28, 2013·Topics in Companion Animal Medicine·Sarah A Moore
Sep 28, 2013·Topics in Companion Animal Medicine·Michael Podell
Sep 28, 2013·Topics in Companion Animal Medicine·Karen R Muñana
Apr 16, 2014·Epilepsia·Robert S FisherSamuel Wiebe
May 9, 2014·Frontiers in Neurology·Carmela GiordanoGiuseppe Biagini
Oct 24, 2014·BMC Veterinary Research·Marios CharalambousHolger A Volk
Sep 5, 2015·The British Journal of Nutrition·Tsz Hong LawHolger A Volk
Nov 27, 2015·Brain : a Journal of Neurology·Pishan ChangRobin S B Williams
Feb 24, 2016·Journal of Veterinary Internal Medicine·M PodellS R Platt
Jun 23, 2016·The Veterinary Record·A WessmannT J Anderson
Jul 13, 2016·Veterinary Record Open·Luisa De RisioAnita Shea
Aug 19, 2016·Expert Review of Neurotherapeutics·Christopher M DeGiorgio, Ameer Y Taha
Feb 9, 2018·PloS One·Rowena M A PackerHolger A Volk
Apr 28, 2018·The Veterinary Record·Joshua WinterHolger Andreas Volk
Aug 1, 2018·Research in Veterinary Science·Benjamin Andreas BerkHolger Andreas Volk

❮ Previous
Next ❯

Citations

Mar 4, 2021·The Veterinary Clinics of North America. Small Animal Practice·Rachel Pilla, Jan S Suchodolski
May 8, 2021·Journal of Veterinary Internal Medicine·Gareth Michael Couper JonesRowena Mary Anne Packer

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation
blood collection

Software Mentioned

R

Related Concepts

Related Feeds

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.