Efficacy of MEM 1003, a novel calcium channel blocker, in delay and trace eyeblink conditioning in older rabbits

Neurobiology of Aging
Gregory M RoseD S Woodruff-Pak

Abstract

Eyeblink conditioning is a relatively simple form of associative learning that shows neurobiological and behavioral parallels across several species, including humans. Aged subjects acquire eyeblink conditioning more slowly than young ones. In addition, eyeblink conditioning effectively discriminates patients with Alzheimer's disease from healthy older adults. The present study evaluated the effect of a novel L-type Ca2+ channel antagonist, MEM 1003, on delay and trace eyeblink conditioning in older (mean 33.4 months old) female New Zealand white rabbits. In the delay conditioning paradigm, an 850 ms tone conditioning stimulus (CS) was followed 750 ms after its onset by a 100 ms corneal air puff. Several trace conditioning paradigms were evaluated, with a silent period of 300, 400 or 500 ms between the end of the tone CS and the delivery of the air puff. Learning was more difficult in the longer trace paradigms than in the delay paradigm. MEM 1003, at a dose of 2.0 mg/kg, s.c., given daily 30 min prior to training on each of the 15 training days, enhanced learning compared to vehicle injections in both delay and trace paradigms. However, higher or lower doses were ineffective. These results support previous work demonstrating t...Continue Reading

References

May 1, 1991·Neurobiology of Aging·C Weiss, R F Thompson
Feb 10, 1989·Science·R A DeyoJ F Disterhoft
May 1, 1972·Journal of Comparative and Physiological Psychology·L W Schmaltz, J Theios
Apr 1, 1984·Physiology & Behavior·D A PowellL L Hernandez
Jan 1, 1983·Neurobiology of Aging·J Harrison, J Buchwald
Jan 1, 1981·Experimental Aging Research·D A PowellL L Hernandez
Nov 1, 1993·Behavioral and Neural Biology·D QuartermainJ Puente
Jun 1, 1996·Behavioral Neuroscience·P R Solomon, M E Groccia-Ellison
Dec 22, 2000·Neurobiology of Learning and Memory·D QuartermainA Kwan
Feb 13, 2001·Neurobiology of Aging·M G KnuttinenJ F Disterhoft
Feb 22, 2001·Neurobiology of Aging·B G SchreursA R McIntosh
Aug 30, 2001·Neurobiology of Learning and Memory·D Quartermain, V Garcia deSoria
Oct 23, 2001·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·D S Woodruff-Pak
Dec 1, 2001·Neurobiology of Learning and Memory·D S Woodruff-PakS K Lemieux
Sep 27, 2003·Alzheimer Disease and Associated Disorders·Mark Barad
Sep 18, 2004·Trends in Neurosciences·Emil C ToescuPhilip W Landfield
Dec 16, 2004·Behavioral Neuroscience·Christian Bellebaum, Irene Daum
Mar 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Geoffrey C TombaughGregory M Rose

❮ Previous
Next ❯

Citations

Jun 27, 2008·Molecular Neurobiology·Donna M Barten, Charles F Albright
Jan 15, 2010·Trends in Neurosciences·Sara N Burke, Carol A Barnes
Jun 19, 2013·The European Journal of Neuroscience·Rachel D Samson, Carol A Barnes
May 20, 2015·The European Journal of Neuroscience·Panos ZanosTodd D Gould
Oct 28, 2008·Neurobiology of Aging·Diana S Woodruff-PakLee-Yuan Liu-Chen
Oct 1, 2010·Reviews in the Neurosciences·Susana Ferrao SantosJean-Noël Octave
Dec 2, 2008·Journal of Cellular and Molecular Medicine·Yif'at BiranPaul A Adlard
Oct 28, 2019·Molecular and Cellular Neurosciences· Sushma, Amal Chandra Mondal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.