Efficacy of Mesenchymal Stromal Cell Therapy for Acute Lung Injury in Preclinical Animal Models: A Systematic Review

PloS One
Lauralyn McIntyreCanadian Critical Care Translational Biology Group

Abstract

The Acute Respiratory Distress Syndrome (ARDS) is a devastating clinical condition that is associated with a 30-40% risk of death, and significant long term morbidity for those who survive. Mesenchymal stromal cells (MSC) have emerged as a potential novel treatment as in pre-clinical models they have been shown to modulate inflammation (a major pathophysiological hallmark of ARDS) while enhancing bacterial clearance and reducing organ injury and death. A systematic search of MEDLINE, EMBASE, BIOSIS and Web of Science was performed to identify pre-clinical studies that examined the efficacy MSCs as compared to diseased controls for the treatment of Acute Lung Injury (ALI) (the pre-clinical correlate of human ARDS) on mortality, a clinically relevant outcome. We assessed study quality and pooled results using random effect meta-analysis. A total of 54 publications met our inclusion criteria of which 17 (21 experiments) reported mortality and were included in the meta-analysis. Treatment with MSCs, as compared to controls, significantly decreased the overall odds of death in animals with ALI (Odds Ratio 0.24, 95% Confidence Interval 0.18-0.34, I2 8%). Efficacy was maintained across different types of animal models and means of ALI...Continue Reading

References

Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Feb 21, 2003·The New England Journal of Medicine·Margaret S HerridgeUNKNOWN Canadian Critical Care Trials Group
May 23, 2006·The New England Journal of Medicine·UNKNOWN National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials NetworkAndrea L Harabin
Oct 13, 2006·JAMA : the Journal of the American Medical Association·Daniel G Hackam, Donald A Redelmeier
Jan 27, 2007·BMJ : British Medical Journal·Daniel G Hackam
Apr 10, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jianguo XuMauricio Rojas
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naveen GuptaMichael A Matthay
Feb 24, 2009·Journal of Clinical Epidemiology·Margaret SampsonCarol Lefebvre
Jun 6, 2009·The American Journal of Pathology·Yuben MoodleyAlan Trounson
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Apr 3, 2010·PLoS Medicine·H Bart van der WorpMalcolm R Macleod
Jun 19, 2010·American Journal of Respiratory and Critical Care Medicine·Shirley H J MeiDuncan J Stewart
Jun 25, 2010·Cell Transplantation·Hiroshi YagiMartin L Yarmush
Jul 29, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hiroshi YagiMartin L Yarmush
May 14, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Huang YangWang Yu-Tong
Jun 22, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jun SunZhong Chao Han
Jul 12, 2011·Critical Care Clinics·Jeffrey E Gotts, Michael A Matthay
Aug 10, 2011·The Journal of Trauma·Edward J HannoushDavid H Livingston
Mar 20, 2012·Osteoarthritis and Cartilage·C KilkennyD G Altman
Mar 20, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anna KrasnodembskayaMichael A Matthay
May 17, 2012·Systematic Reviews·Sara KhanguraDavid Moher
Jun 16, 2012·Journal of Cellular and Molecular Medicine·Zhao-hui QinLong Yu
Aug 7, 2012·Surgery·Edward J HannoushDavid H Livingston
Oct 2, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lavinia IonescuBernard Thébaud
Dec 5, 2012·Respiration; International Review of Thoracic Diseases·Rebecca LimGraham Jenkin
Jan 5, 2013·International Journal of Medical Sciences·Soyoung ShinSeungphil Choi

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Citations

May 20, 2016·Critical Care : the Official Journal of the Critical Care Forum·Adrien BougléFabrice Chrétien
Aug 5, 2016·Expert Opinion on Biological Therapy·Fernanda F CruzPatricia R M Rocco
Dec 14, 2016·Cell and Tissue Research·Collin T Stabler, Edward E Morrisey
Dec 29, 2017·The Journal of Trauma and Acute Care Surgery·Sawyer SmithMartin Schreiber
Nov 18, 2016·PloS One·Marc T AveyUNKNOWN Canadian Critical Care Translational Biology Group
Mar 24, 2018·F1000Research·Peter WohlrabKlaus Ulrich Klein
Feb 28, 2018·Stem Cell Research & Therapy·Luisa H A SilvaPatricia R M Rocco
Mar 21, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mark J McVeyWolfgang M Kuebler
Jun 19, 2019·Journal of Intensive Care Medicine·Shawn KakuWare G Kuschner
Oct 2, 2019·American Journal of Respiratory Cell and Molecular Biology·Amy L RyanDarcy E Wagner
Jul 10, 2019·Stem Cells Translational Medicine·Martin J Hoogduijn, Eleuterio Lombardo
Sep 6, 2019·Cell Biology and Toxicology·Miquéias Lopes-PachecoPaolo Pelosi
Mar 7, 2020·Journal of Clinical Medicine·Judith BehnkeHarald Ehrhardt
May 2, 2020·American Journal of Respiratory and Critical Care Medicine·Lorenzo Del Sorbo, Eddy Fan
Nov 23, 2017·Frontiers in Physiology·Alana WestoverTimothy J Moss
Dec 24, 2018·Critical Care : the Official Journal of the Critical Care Forum·Mohammad Reza Mokhber DezfouliRoshanak Mokhtari
Sep 9, 2020·Stem Cell Reviews and Reports·José Lucas Martins RochaKelen Cristina Ribeiro Malmegrim
Aug 9, 2020·Frontiers in Cell and Developmental Biology·Noemi EiroFrancisco J Vizoso
Dec 24, 2018·Frontiers in Pharmacology·Allan K N AlencarGisele Zapata-Sudo
May 20, 2020·Journal of Translational Medicine·Christopher J RogersBoris R Minev
May 13, 2020·Respiratory Research·Sirous Sadeghian ChaleshtoriMassoumeh Jabbari Fakhr
Apr 9, 2020·The European Respiratory Journal·Maroun KhouryDaniel J Weiss
Oct 12, 2017·The Journal of Trauma and Acute Care Surgery·Ben AntebiLeopoldo C Cancio
Jul 29, 2020·Frontiers in Immunology·Felipe Saldanha-AraujoJuliana Lott Carvalho
Jul 24, 2020·Cellular and Molecular Life Sciences : CMLS·Luis A CostaFrancisco J Vizoso
Oct 10, 2020·Human Cell·Hugo C RodriguezAshim Gupta
Nov 4, 2020·British Journal of Pharmacology·Rachele CiccocioppoFranco Locatelli

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