Efficacy of mifepristone in reducing intermenstrual vaginal bleeding in users of the levonorgestrel intrauterine system

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Suman LalNutan Agarwal

Abstract

To evaluate the efficacy of mifepristone to reduce intermenstrual bleeding in levonorgestrel intrauterine system (LNG-IUS) users. In this prospective, open-label, comparative study, 36 women using the LNG-IUS for menorrhagia received 100mg of mifepristone every 30 days for 3 months (group 1). Fifty age-matched LNG-IUS users who did not receive any drugs were used as the comparison group (group 2). Menstrual bleeding days, pictorial blood loss assessment chart (PBAC) score, and intermenstrual bleeding/spotting days were compared between the 2 groups at 3 months (during treatment) and at 6 months (3 months post treatment). Baseline characteristics were comparable between the groups. At 3 months, median duration and episodes of intermenstrual bleeding/spotting were significantly lower in group 1 compared with group 2 (6 vs 12.5 days, P=0.01; 2.5 vs 3, P=0.05, respectively). More women were satisfied with the LNG-IUS in the mifepristone group compared with the control group (75% vs 44%; P=0.004). At 6 months, the median duration of intermenstrual bleeding/spotting was significantly lower in group 1 compared with group 2 (6 vs 15 days; P=0.008). Mifepristone was effective in reducing the number of episodes and duration of intermenst...Continue Reading

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Citations

Feb 23, 2010·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Takeshi Maruo
Nov 26, 2015·Obstetrics and Gynecology Clinics of North America·EmmaKate Friedlander, Bliss Kaneshiro
Nov 12, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yayi SunZhiying Hu
Jul 28, 2010·The Journal of Family Planning and Reproductive Health Care·Julia Chandler, Kate Nash
Nov 30, 2019·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Mariana FavaLuis Bahamondes
Feb 14, 2012·Applied Biochemistry and Biotechnology·Nivedita SinghVikas Pruthi
Aug 8, 2020·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·P A H H van der HeijdenM Y Bongers

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