Efficacy of modest dose irradiation in combination with long-term endocrinal treatment for high-risk prostate cancer: a preliminary report

Japanese Journal of Clinical Oncology
Tomonari SasakiHiroshi Honda

Abstract

Although radiotherapy in combination with endocrinal manipulation has been identified as an effective treatment for patients with high-risk prostate cancer, the optimal dose for locoregional control of prostate cancer in combination with hormonal therapy has not yet been determined. The efficacy of modest doses of irradiation (60-62 Gy) combined with long-term endocrinal treatment for patients with high-risk prostate cancer (defined as a pretreatment prostate-specific antigen (PSA) level greater than 20 ng/ml or a Gleason's score of 8-10 or T3-T4 disease) was analyzed in 60 Japanese patients. The patients included in this study had received radical radiotherapy with long-term endocrinal manipulation in the period between 1993 and 2000. The median age of the patients was 70 years (range, 56-83). Neoadjuvant hormonal therapy with a median duration of 3.9 months was performed prior to radiotherapy, and hormonal therapy was continued until recurrence. A median dose of 61.4 Gy (range, 44-71.4) was delivered to the prostate. Pelvic node irradiation was performed in 49 patients (81.6%). After a median follow-up period of 28.5 months, the overall survival, cause-specific survival and biochemical relapse-free survival at 3 years were 94...Continue Reading

References

Jul 15, 1997·International Journal of Radiation Oncology, Biology, Physics·A L ZietmanJ J Park
Mar 31, 1999·International Journal of Radiation Oncology, Biology, Physics·F A ViciniA A Martinez
Nov 24, 1999·European Urology·C J Tyrrell
Dec 10, 1999·International Journal of Cancer. Journal International Du Cancer·A W HsingS S Devesa
Mar 4, 2000·International Journal of Radiation Oncology, Biology, Physics·P A KupelianC A Reddy
Jun 6, 2000·International Journal of Radiation Oncology, Biology, Physics· Roach M 3RDM Mohuidden
Jul 20, 2002·International Journal of Radiation Oncology, Biology, Physics·Alan PollackIsaac Rosen
Apr 4, 2003·Japanese Journal of Clinical Oncology·Katsumasa NakamuraUNKNOWN Japanese PCS Working Subgroup of Prostate Cancer
Apr 16, 2003·International Journal of Radiation Oncology, Biology, Physics·Katsuyuki KarasawaTadayoshi Matsuda

❮ Previous
Next ❯

Citations

Oct 19, 2010·International Journal of Radiation Oncology, Biology, Physics·Kazuhiko OgawaUNKNOWN Japanese Patterns of Care Study Working Subgroup of Prostate Cancer
Jul 20, 2016·Japanese Journal of Clinical Oncology·Masaki ShiotaMasatoshi Eto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.