Efficacy of mometasone furoate microemulsion in the treatment of erosive-ulcerative oral lichen planus: pilot study

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
J M AguirreA Ponte

Abstract

Oral lichen planus (OLP) is a frequent immunological chronic disease, having different clinical forms: asymptomatic and symptomatic. Symptomatic OLP has been palliated with topical corticosteroids with different levels of efficacy and safety. The purpose of this pilot phase II clinical trial was to determine the efficacy of mometasone furoate microemulsion upon the symptoms and signs of erosive-ulcerative OLP. Forty-nine patients with clinical and histologically confirmed erosive-ulcerative OLP were enrolled in this study (36 women and 13 men). Their average age was 56.4 years (from 28 to 78). The treatment consisted of 0.1% mometasone furoate microemulsion mouthwash three times a day over 30 days. Pain, erythema and ulceration were assessed after 15 and 30 days of treatment. The data was processed and statistically analysed by student's t-test for paired samples. Mometasone caused a statistically significant reduction in pain (3.58 vs. 0.65, P = 0.0000). Treatment significantly reduced the surface area of erythema (155.2 vs. 21.9 mm(2), P = 0.0001) and ulceration (30.7 vs. 7.3 mm(2), P = 0.0000). None of these patients suffered severe adverse effects. Mometasone furoate microemulsion is a safe and effective therapy in the trea...Continue Reading

Citations

Dec 25, 2008·Journal of Oral Science·Kobkan Thongprasom, Kittipong Dhanuthai
Jan 8, 2013·Contemporary Clinical Dentistry·Archana PatilG P Sujatha
Jun 10, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Juan XiaBin Cheng
Jan 24, 2014·Case Reports in Dentistry·Chiyadu PadminiM Shilpa Reddy
Aug 28, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Sara TejaniSook-Bin Woo
Jul 3, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·H Husein-ElAhmedM Steinhoff
Mar 20, 2020·Journal of Oral and Maxillofacial Pathology : JOMFP·Shamimul HasanSafia Siddiqui

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