Efficacy of monensin sodium for the reduction of fecal shedding of Mycobacterium avium subsp. paratuberculosis in infected dairy cattle

Preventive Veterinary Medicine
Steven H HendrickTodd F Duffield

Abstract

Reducing the quantity of Mycobacterium avium subsp. paratuberculosis (MAP) being shed by cows with Johne's disease should decrease the risk of spread of this disease to young stock. Previous work has suggested that monensin sodium decreases the pathologic lesions associated with Johne's disease, but the impact on shedding of viable MAP remains unknown. After serologic screening of 32 dairy herds in southwestern Ontario, 228 cows from 13 of these herds were enrolled into a randomized clinical trial. Fecal culture and PCR were used to identify 114 cows as potential fecal shedders, while another 114 cows were enrolled as ELISA negative, herd and parity matched controls. All cows were randomized to receive either a monensin controlled release capsule (CRC) or a placebo capsule. Serial fecal and blood samples were collected for fecal culture and serum ELISA testing over a 98-day period. On day 98 of the study, treatments were switched for all cows continuing in the trial. These remaining cows were followed for another 98 days with a similar sampling protocol. Mixed effect models were used to measure the impact of treatment on the number of colony forming units identified on fecal cultures over time. During the first 98 days of the s...Continue Reading

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Citations

Jul 26, 2011·Journal of Veterinary Internal Medicine·M-E FecteauR W Sweeney
Sep 2, 2011·American Journal of Veterinary Research·Marie-Eve FecteauRaymond W Sweeney
Nov 4, 2005·Journal of the American Veterinary Medical Association·Steven H HendrickTodd F Duffield
Oct 26, 2011·The Veterinary Clinics of North America. Food Animal Practice·Marie-Eve Fecteau, Robert H Whitlock
May 24, 2011·Preventive Veterinary Medicine·Ian A GardnerShigetoshi Eda
Jun 22, 2006·Preventive Veterinary Medicine·Steven H HendrickDavid F Kelton
Jan 17, 2012·Critical Reviews in Microbiology·Rodrick J ChiodiniRichard W McCallum
Jul 8, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Robert J GreensteinSheldon T Brown
Oct 31, 2012·Journal of Veterinary Internal Medicine·R W SweeneyA J Roussel

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