Efficacy of monepantel, derquantel and abamectin against adult stages of a multi-resistant Haemonchus contortus isolate.

Parasitology Research
Heinz SagerRonald Kaminsky

Abstract

Drug resistance in gastrointestinal nematodes is a severe problem for sheep farmers. With the recent introduction of monepantel (Zolvix®) and of derquantel plus abamectin (Startect®) in New Zealand, two new anthelmintic classes will be available to control gastrointestinal nematodes. While monepantel covers a broad spectrum of nematodes, the efficacy of derquantel is mid-spectrum and limited to a smaller number of species and stages. The combination of derquantel and abamectin allows to enlarge the spectrum and to cover most parasitic nematodes in sheep. However, the question remained open, if the efficacy of the new anthelmintics can be maintained in the presence of severe anthelmintic resistance. The present study investigated the efficacy against adult stages of a multi-resistant Haemonchus contortus isolate. While monepantel resulted in 100 % elimination, derquantel in combination with abamectin resulted in efficacies <95 % (faecal egg counts and worm counts).

Citations

May 15, 2013·Veterinary Parasitology·Ronald KaminskyHeinz Sager
Dec 18, 2014·International Journal for Parasitology. Drugs and Drug Resistance·Andrew C KotzeRoger K Prichard
Dec 12, 2012·Veterinary Parasitology·Francisco A Rojo-Vázquez, Barry C Hosking
Feb 5, 2013·Trends in Parasitology·Christian Epe, Ronald Kaminsky
Mar 17, 2015·Veterinary Parasitology·R Van den BromP Vellema
Mar 17, 2016·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Jordana Andrioli Salgado, Clóvis de Paula Santos
Sep 10, 2014·Parasitology·L LecováL Skálová
Oct 27, 2017·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Plínio Aguiar de OliveiraAna Lucia Schild

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.