Efficacy of montelukast, a leukotriene receptor antagonist, for the treatment of dysmenorrhea: a prospective, double-blind, randomized, placebo-controlled study

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Hiroyuki FujiwaraMitsuaki Suzuki

Abstract

To investigate the effectiveness of montelukast, a leukotriene receptor antagonist, in alleviating the symptoms of dysmenorrhea. This prospective, double-blind, randomized, placebo-controlled study was comprised of 62 patients with dysmenorrhea who were randomly divided into 2 groups (montelukast and placebo). Data obtained from 50 patients were analyzed (montelukast: 24; placebo: 26). Using visual analog scale (VAS) scores and nonsteroidal anti-inflammatory drug (NSAID) usage per menstrual cycle, values before treatment were compared to average scores over two menstrual cycles with treatment. Both the VAS scores and NSAID usage decreased significantly in both groups. The decreases were greater in the montelukast group compared to the placebo group, but the differences were not statistically significant. Nevertheless, in "highly effective cases," which were defined as having a post-treatment value less than half of the pre-treatment value, the decreases were significantly greater in the montelukast group than in the placebo group (VAS: montelukast, 4 vs. placebo, 0 (P=0.029); NSAID: montelukast, 9 vs. placebo, 3 (P=0.031)). The present study found that montelukast may be effective in alleviating pain associated with dysmenorrhe...Continue Reading

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Citations

May 21, 2013·Biochemical Pharmacology·Astrid Stefanie KahntThorsten Jürgen Maier
Dec 3, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sadiman Kiykac AltinbasUmit Goktolga
Apr 18, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Ilker InceMine Celik

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