Efficacy of mosapride citrate in proximal gastric accommodation and gastrointestinal motility in healthy volunteers: a double-blind placebo-controlled ultrasonographic study.

Journal of Gastroenterology
Hiroaki KusunokiAkiko Shiotani

Abstract

Mosapride citrate, a 5-hydroxytryptamine-4 receptor agonist, enhances antral contractions and gastric emptying, but its effects on proximal gastric accommodation and gastroduodenal motility have not been fully studied. The aim of the present study was to clarify the effects of mosapride citrate on proximal gastric accommodation and gastroduodenal motility in healthy volunteers, using ultrasonography. Fourteen healthy volunteers (mean age 25.3 years) were treated for 14 days with mosapride citrate (15 mg b.d.) or a placebo in a double-blind randomized fashion. Before and after drug treatment, ultrasonographic assessment of gastroduodenal motility was performed. For assessment of the gastric accommodation reflex, the cross-sectional area of the proximal stomach was measured after the incremental ingestion, with a straw, of up to 400 ml of a liquid meal (consommé soup: 13.1 kcal, 400 ml); this was done with the subject in a supine position. Gastric emptying, antral contractions, and the duodenogastric reflux were observed as described previously. In the subjects treated with mosapride citrate, the expansion rate of the cross-sectional area of the proximal stomach was significantly greater after the ingestion of 400 ml as compared ...Continue Reading

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Citations

May 12, 2011·The Journal of Veterinary Medical Science·Atsushi TsukamotoHajime Tsujimoto
Dec 29, 2010·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Hiroaki KusunokiAkiko Shiotani
Sep 10, 2013·Journal of Gastroenterology·Kousuke FukazawaYoshikazu Kinoshita
Mar 29, 2014·Expert Opinion on Emerging Drugs·William L Hasler
Mar 6, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H KusunokiJ Tack
Aug 14, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y SekinoM Inamori
Apr 5, 2013·Journal of Magnetic Resonance Imaging : JMRI·Marije P van der PaardtJaap Stoker
Aug 26, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T AmanoS Fukudo
Jun 14, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Kyung-Min ShinChang-Gue Son
Jan 10, 2020·Journal of Neurogastroenterology and Motility·Jung Hwan OhUNKNOWN Functional Dyspepsia Research Group and Clinical Practice Guidelines Group Under the Korean Society of Neurogastroenterology
Mar 30, 2019·Alimentary Pharmacology & Therapeutics·Imke MasuyJan Tack

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