PMID: 9532644Apr 9, 1998Paper

Efficacy of moxonidine, an imidazoline receptor agonist, in patients with essential hypertension

Terapevticheskiĭ arkhiv
E V BaliakinaA P Iurenev

Abstract

Study of zint (moxonidine), a hypotensive drug with the central mechanism of action. The hemodynamics and platelet functional activity were assessed in 30 patients with essential hypertension treated by zint in a daily dose of 0.4 mg, taken in the morning, for 3 months. By the end of treatment the systolic arterial pressure decreased by 23 +/- 4 mm Hg, diastolic by 15 +/- mm Hg, mean pressure by 17 +/- 2 mm Hg, and heart rate by 5 +/- 4 str/min. Echography showed that myocardial hypertrophy decreased but negligibly. An evident decrease of ADP-induced platelet aggregation was observed. Zint therapy may be a most physiological method of arterial hypertension control.

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

© 2022 Meta ULC. All rights reserved