Efficacy of musical interventions in dementia: methodological requirements of nonpharmacological trials

Annals of the New York Academy of Sciences
Séverine SamsonNathalie Ehrlé

Abstract

The management of patients with Alzheimer's disease is a significant public health problem given the limited effectiveness of pharmacological therapies combined with iatrogenic effects of drug treatments in dementia. Consequently, the development of nondrug care, such as musical interventions, has become a necessity. The experimental rigor of studies in this area, however, is often lacking. It is therefore difficult to determine the impact of musical interventions on patients with dementia. As part of a series of studies, we carried out randomized controlled trials to compare the effectiveness of musical activities to other pleasant activities on various functions in patients with severe Alzheimer's disease. The data obtained in these trials are discussed in light of the methodological constraints and requirements specific to these clinical studies. Although the results demonstrate the power of music on the emotional and behavioral status of patients, they also suggest that other pleasant activities (e.g., cooking) are also effective, leaving open the question about the specific benefits of music in patients with dementia. All these findings highlight the promising potential for nonpharmacological treatments to improve the well...Continue Reading

References

Apr 17, 2001·Annals of Internal Medicine·D G AltmanUNKNOWN CONSORT GROUP (Consolidated Standards of Reporting Trials)
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·A J Blood, R J Zatorre
Dec 19, 2003·Annals of the New York Academy of Sciences·Stephanie KhalfaSonia J Lupien
Mar 14, 2007·Journal of Music Therapy·Takiko Takahashi, Hiroko Matsushita
Jul 12, 2008·Dementia and Geriatric Cognitive Disorders·Melanie LuppaSteffi G Riedel-Heller
Feb 14, 2009·Neuropsychology Review·Amee Baird, Séverine Samson
Aug 14, 2009·Annals of the New York Academy of Sciences·Séverine SamsonHervé Platel
Jan 11, 2011·Nature Neuroscience·Valorie N SalimpoorRobert J Zatorre
Jan 24, 2012·Consciousness and Cognition·Mohamad El HajPhilippe Allain
Jan 27, 2012·International Journal of Geriatric Psychiatry·G BellelliM Trabucchi
Oct 20, 2012·International Journal of Geriatric Psychiatry·Orii McDermottMartin Orrell
Aug 24, 2013·Journal of Alzheimer's Disease : JAD·Pauline NarmeSéverine Samson

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Citations

Mar 12, 2016·Journal of Alzheimer's Disease : JAD·Katlyn J PeckAlexandra J Fiocco
Feb 6, 2017·Translational Neurodegeneration·Rong FangDavid P Calimag
Jul 24, 2018·The Cochrane Database of Systematic Reviews·Jenny T van der SteenAnnemiek C Vink
Mar 10, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Bing XuXu Wang
Jul 11, 2018·Dementia & Neuropsychologia·Shirlene Vianna MoreiraMarcos Moreira
Jun 18, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Jianwen ChenWeidong Le
May 4, 2017·The Cochrane Database of Systematic Reviews·Jenny T van der SteenAnnemiek C Vink
Dec 4, 2020·Acta Pharmacologica Sinica·Feng ZhangWei-Dong Le
Mar 9, 2020·Journal of the American Medical Directors Association·Debra BakerjianSandra Taylor

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