Efficacy of narrow-band ultraviolet-B therapy in patch-stage mycosis fungoides: A clinical study and review of the literature.

Photodermatology, Photoimmunology & Photomedicine
Tugba Atci, Can Baykal

Abstract

We investigated the efficacy of narrow-band UVB in patch-stage MF and reviewed the literature to re-evaluate the role of this phototherapy method in early MF. Early-stage MF patients treated with narrow-band UVB were included. Number of narrow-band UVB treatment sessions, treatment duration, cumulative UV dose, clinical response results, side effects, duration of the remission period and relapse rate were evaluated. Complete response rate was 86.7% in sixty patients with MF. Mean number of treatment sessions was 62.9 ± 15.1, treatment duration was 32.1 ± 10.7 weeks, and mean cumulative UV dose was 62.1 ± 41.9 J/cm2 in patients with complete response. Mean duration of remission was 10.3 ± 11.0 months, and relapse rate was 70% in a mean follow-up of 21.9 ± 16.4 months. Mild regional erythema (6.7%) and pruritus (8.3%) were main side effects. There were no significant differences between stage IA and stage IB patients in terms of treatment parameters and duration of remission period. Our study confirms that narrow-band UVB is effective for the management of the patch-stage MF without serious side effects. Extent of the skin lesions did not affect the efficacy of phototherapy. However, due to the short duration of remission, a furt...Continue Reading

References

Jun 29, 2000·Archives of Dermatology·C ClarkJ Ferguson
Jul 26, 2002·Journal of the American Academy of Dermatology·Raechele Cochran GathersHenry W Lim
Feb 13, 2003·Journal of the American Academy of Dermatology·Pascale V M M DiederenWillem A van Vloten
Dec 31, 2003·The British Journal of Dermatology·S J WhittakerUNKNOWN U.K. Cutaneous Lymphoma Group
Jun 15, 2005·Clinical and Experimental Dermatology·S Z GhodsiC Chams-Davatchi
Jul 16, 2005·Journal of the American Academy of Dermatology·Gonca BoztepeFikret Kilemen
Jan 13, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·Y KuralN Büyükbabani
Apr 1, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Franz TrautingerSean Whittaker
May 11, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·F PavlotskyH Trau
Aug 11, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·G GökdemirA Köşlü
Aug 28, 2007·Acta Dermato-venereologica·Kashif AhmadPaul Collins
Nov 8, 2007·Photodermatology, Photoimmunology & Photomedicine·V BrazzelliG Borroni
Oct 4, 2008·Dermatology : International Journal for Clinical and Investigative Dermatology·Olivier DereureBernard Guillot
Oct 10, 2008·Journal of the American Academy of Dermatology·Joi Carter, Kathryn A Zug
Nov 26, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·P PonteM Apetato
Dec 8, 2011·Annals of Dermatology·Min Soo JangSang Tae Kim
Jan 27, 2012·Clinical and Experimental Dermatology·S KanokrungseeV Vachiramon
Oct 4, 2012·The Journal of Dermatological Treatment·Gonca ElcinSedef Sahin

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Citations

Jun 13, 2021·Revista española de geriatría y gerontología·Andrea Montes-TorresLucía Prieto-Torres
Sep 28, 2021·Current Treatment Options in Oncology·Caitlin M BrumfielAaron R Mangold

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