Efficacy of nasal irrigation with 200 μg/mL amphotericin B after functional endoscopic sinus surgery: a randomized, placebo-controlled, double-blind study

International Forum of Allergy & Rhinology
Rong-San JiangKai-Li Liang

Abstract

Previous studies have shown controversial results of topical amphotericin B (AMB) nasal irrigation for chronic rhinosinusitis (CRS). The purpose of this study was to evaluate the efficacy of 200 μg/mL AMB nasal irrigation as an adjuvant therapy after functional endoscopic sinus surgery (FESS). Patients with CRS who had received FESS for treatment were recruited and assigned to 1 of 2 groups at random at 1 month postsurgery. In the AMB group patients received nasal irrigation with 200 μg/mL of AMB for 2 months on a daily basis. In the control group normal saline irrigation was given instead. Before FESS and before and after nasal irrigation, patients' sinonasal symptoms were assessed through a questionnaire that was a Taiwanese version of the 22-item Sino-Nasal Outcome Test (TWSNOT-22). In addition, patients received endoscopic examination, acoustic rhinometry, smell test, saccharine transit test, and bacterial cultures obtained from their middle meati. A total of 73 patients completed the study between December 2014 and January 2017. Among them, 37 received nasal irrigation with AMB solution, and 36 with saline. In the AMB group, scores of TWSNOT-22 dropped significantly after irrigation compared with before (p = 0.005). In the...Continue Reading

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Citations

Dec 22, 2017·International Forum of Allergy & Rhinology·Kevin C Welch
Dec 4, 2019·Current Opinion in Otolaryngology & Head and Neck Surgery·Neil C W Tan, Alkis J Psaltis
Apr 24, 2018·International Journal of Otolaryngology·Shang-Heng WuRong-San Jiang
Mar 27, 2019·Allergy, Asthma & Immunology Research·Jian Jiao, Luo Zhang
Nov 26, 2020·International Forum of Allergy & Rhinology·Richard R OrlandiBing Zhou

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