Efficacy of non-carbapenem antibiotics for pediatric patients with first febrile urinary tract infection due to extended-spectrum beta-lactamase-producing Escherichia coli

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
Yoshifusa AbeKazuo Itabashi

Abstract

Although carbapenem is the recommended for urinary tract infection (UTI) caused by extended-spectrum beta-lactamase (ESBL)-producing organisms, non-carbapenems have been reported to be effective for adult patients with UTI caused by ESBL-producing organisms. The purpose of this study was to evaluate the efficacy of non-carbapenems for pediatric patients with UTI due to ESBL-producing Escherichia coli (E. coli) based on the microbiologic and clinical outcomes. Fifteen children, who were treated for first febrile UTI caused by ESBL-producing E. coli were enrolled in this study. Antimicrobial susceptibilities and ESBL production were determined according to the Clinical and Laboratory Standards Institute guidelines. To detect CTX-M genes, polymerase chain reaction was performed with specific primers for blaCTX-M detection. Of the 15 enrolled patients, 10 (66.7%) were boys and 5 (33.3%) were girls, with a median age of four months. VUR was detected in six patients (40%). For detection of blaCTX-M by PCR, CTX-M-3, CTX-M-8, CTX-M-14, and CTX-M-15 were detected in five, one, eight, and one patient, respectively. Overall, 14 of the 15 isolates (93.3%) were susceptible for fosfomycin (FOM), and all isolates were susceptible for cefmetaz...Continue Reading

Citations

Dec 29, 2018·Recent Patents on Inflammation & Allergy Drug Discovery·Alexander K C LeungKam L Hon
Jul 31, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Elsa Roldan-MasedoAna Méndez-Echevarría
Feb 18, 2021·Journal of the Pediatric Infectious Diseases Society·Marie E WangAlan R Schroeder
Sep 5, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Ji Yeon SongSeong Heon Kim

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