PMID: 9165992Apr 1, 1997Paper

Efficacy of non-steroidal anti-inflammatory drugs for low back pain: a systematic review of randomised clinical trials

Annals of the Rheumatic Diseases
Bart W KoesLex M Bouter

Abstract

To assess the efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) for low back pain. Computer aided search of published randomised clinical trials and assessment of the methods of the studies. 26 randomised clinical trials evaluating NSAIDs for low back pain were identified. Score for quality (maximum = 100 points) of the methods based on four categories: study population; interventions; effect measurement; data presentation and analysis. Determination of success rate per study group and evaluation of different contrasts. Statistical pooling of placebo controlled trials in similar patient groups and using similar outcome measures. The methods scores of the trials ranged from 27 to 83 points. NSAIDs were compared with placebo treatment in 10 studies. The pooled odds ratio in four trials comparing NSAIDs with placebo after one week was 0.53 (95% confidence intervals 0.32 to 0.89) using the fixed effect model, indicating a significant effect in favour of NSAIDs compared with placebo. In nine studies NSAIDs were compared with other (drug) therapies. Of these, only two studies reported better results of NSAIDs compared with paracetamol with and without dextropropoxyphene. In the other trials NSAIDs were not better than the re...Continue Reading

References

Oct 1, 1992·Annals of Internal Medicine·P G ShekelleR H Brook
Mar 1, 1992·Journal of Clinical Epidemiology·V A LawrenceW O Spitzer
Jun 29, 1991·BMJ : British Medical Journal·B W KoesP G Knipschild
Nov 23, 1991·BMJ : British Medical Journal·B W KoesP G Knipschild
Jun 13, 1991·The New England Journal of Medicine·P M Brooks, R O Day
Mar 1, 1985·Progress in Cardiovascular Diseases·S YusufP Sleight
Feb 4, 1988·The New England Journal of Medicine·J W Frymoyer
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Sep 28, 1968·Lancet·E L Radin, R S Bryan
Jan 1, 1968·Acta Orthopaedica Scandinavica·I Goldie
Aug 26, 1983·JAMA : the Journal of the American Medical Association·R A Deyo
Jan 1, 1984·Current Medical Research and Opinion·T VidemanT Partanen
Jan 1, 1980·Current Medical Research and Opinion·D P EvansR G Newcombe
Apr 1, 1982·Annals of the Rheumatic Diseases·H BerryD R Swinson
May 1, 1981·Controlled Clinical Trials·T C ChalmersA Ambroz
Aug 1, 1994·Journal of Clinical Epidemiology·B W KoesL M Bouter
Feb 1, 1995·JAMA : the Journal of the American Medical Association·K F SchulzD G Altman
Jun 1, 1994·Spine·D C CherkinG Waddell
Aug 1, 1995·Pain·Maurits W van TulderLex M Bouter

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Citations

Dec 12, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R M FrancisP Wilkinson
Jun 3, 2006·Clinical Rheumatology·Thomas J Schnitzer
Jan 30, 2004·The Spine Journal : Official Journal of the North American Spine Society·Kevin J PauzaNikolai Bogduk
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Charles A BirbaraUNKNOWN Etoricoxib Protocol 042 Study Group
Jan 11, 2002·The Clinical Journal of Pain·D E Moulin
Apr 20, 2006·Spine·Steven D GlassmanKeith Bridwell
Mar 17, 2001·Journal of General Internal Medicine·S J Atlas, R A Deyo
Jul 15, 2015·Expert Opinion on Drug Delivery·Renan G BritoLucindo J Quintans-Júnior
Nov 26, 2005·Current Medical Research and Opinion·Eija KalsoJan Sörensen
Dec 3, 2014·Advanced Drug Delivery Reviews·S B G BlanquerA A Poot
May 1, 2012·Best Practice & Research. Clinical Gastroenterology·Denis M McCarthy
Jan 1, 2008·The Spine Journal : Official Journal of the North American Spine Society·Gerard Malanga, Erin Wolff
Jan 16, 1998·Baillière's Clinical Rheumatology·S J BradyL M Kenyon
Nov 28, 2006·European Journal of Pain : EJP·Brona M FullenDeirdre A Hurley
Oct 7, 2008·Journal of Clinical Pharmacy and Therapeutics·S-T ChangK-C Tsai
Jul 11, 2012·British Journal of Clinical Pharmacology·Klaus SchafflerWolfram Nothaft
Oct 18, 2005·Journal of Manipulative and Physiological Therapeutics·Craig F NelsonThomas LaBrot
Mar 17, 2010·Best Practice & Research. Clinical Rheumatology·Steven J KamperElaine Hay
Oct 13, 2011·Advances in Orthopedics·Kieran Michael HirparaAshley R Poynton
Jun 30, 2004·Journal of Pain and Symptom Management·Thomas J SchnitzerSheldon X Kong
Oct 17, 2002·Physical Medicine and Rehabilitation Clinics of North America·Anthony Chiodo, Andrew J Haig
Jan 26, 2017·The Korean Journal of Pain·Idiris Altun, Kasım Zafer Yüksel
Feb 12, 2002·Clinical Rehabilitation·Daphne SmithPeter Disler
Sep 12, 2012·Forschende Komplementärmedizin = Research in Complementary Medicine·Harald Walach
Mar 14, 2003·Muscle & Nerve·Steven J Atlas, Rachel A Nardin
Jan 6, 2007·Neurosurgery·Daniel Mazanec, Anantha Reddy
May 13, 2004·Regional Anesthesia and Pain Medicine·Noor M Gajraj
Sep 25, 2014·American Journal of Therapeutics·Bill H McCarberg, Byron Cryer
Oct 27, 2004·The Clinical Journal of Pain·Nikolai Bogduk
Aug 4, 2006·The Journal of the American Academy of Orthopaedic Surgeons·Francis H ShenGunnar B J Andersson
Nov 18, 2009·Disease-a-month : DM·Daniel RothJoseph T Alleva

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