Efficacy of norfloxacin and doxycycline for treatment of vibrio cholerae 0139 infection

The Journal of Antimicrobial Chemotherapy
D DuttaG B Nair

Abstract

An open randomised controlled clinical trial with 160 adults with acute watery diarrhoea and severe dehydration compared the efficacy of varying regimens of norfloxacin and doxycycline for the treatment of cholera caused by Vibrio cholerae 0139 Bengal. Data were analysed for the 111 patients who were faeces culture positive for V. cholerae 0139. In addition to rehydration therapy, 28 patients received 300 mg of doxycycline as a single dose on admission, 26 patients received norfloxacin 400 mg bd for three days, 28 patients received a single dose of 800 mg of norfloxacin and 29 patients received no antibiotic (control group). Patients in the three treatment groups and control group had comparable characteristics on admission. All three treatment groups had reduced stool output, duration of diarrhoea and fluid intake compared with the control group. Multidose norfloxacin treatment significantly reduced stool output, duration of diarrhoea and fluid requirement compared with the other regimens.

Citations

Jul 27, 2001·Current Treatment Options in Gastroenterology·Saurabh Mehandru, Edmund J. Bini
Jan 16, 2004·Gut·A C Casburn-Jones, M J G Farthing
May 17, 2017·Journal of Separation Science·Imran AliLeonid Asnin
Jun 20, 2014·The Cochrane Database of Systematic Reviews·Ya'ara Leibovici-WeissmanMical Paul
Jun 27, 2000·Gastroenterology·S Banerjee, J T LaMont

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