Efficacy of novel synthetic bone substitutes in the reconstruction of large segmental bone defects in sheep tibiae

Biomedical Materials
Jiao Jiao LiH Zreiqat

Abstract

The treatment of large bone defects, particularly those with segmental bone loss, remains a significant clinical challenge as current approaches involving surgery or bone grafting often do not yield satisfactory long-term outcomes. This study reports the evaluation of novel ceramic scaffolds applied as bone graft substitutes in a clinically relevant in vivo model. Baghdadite scaffolds, unmodified or modified with a polycaprolactone coating containing bioactive glass nanoparticles, were implanted into critical-sized segmental bone defects in sheep tibiae for 26 weeks. Radiographic, biomechanical, μ-CT and histological analyses showed that both unmodified and modified baghdadite scaffolds were able to withstand physiological loads at the defect site, and induced substantial bone formation in the absence of supplementation with cells or growth factors. Notably, all samples showed significant bridging of the critical-sized defect (average 80%) with evidence of bone infiltration and remodelling within the scaffold implant. The unmodified and modified baghdadite scaffolds achieved similar outcomes of defect repair, although the latter may have an initial mechanical advantage due to the nanocomposite coating. The baghdadite scaffolds ...Continue Reading

References

Oct 1, 1991·Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials·C J Damien, J R Parsons
Sep 20, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K EidJ Glowacki
Jun 25, 2002·International Orthopaedics·L GaloisJ P Delagoutte
Apr 23, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Frank C den BoerHenk J Th M Haarman
Oct 7, 2004·Macromolecular Bioscience·António J SalgadoRui L Reis
Apr 30, 2005·Biomaterials·Vassilis Karageorgiou, David Kaplan
Sep 29, 2005·Injury·Peter V GiannoudisEleftherios Tsiridis
Dec 13, 2005·Biomaterials·Qizhi Z ChenAldo R Boccaccini
Jun 9, 2006·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·C KnabeM Stiller
Feb 14, 2007·Journal of Biomedical Materials Research. Part a·M D KofronC T Laurencin
Mar 20, 2008·The Journal of Bone and Joint Surgery. American Volume·Yusuf KhanCato T Laurencin
Apr 9, 2008·Archives of Biochemistry and Biophysics·Jonathan I Dawson, Richard O C Oreffo
Jun 10, 2008·Journal of Tissue Engineering and Regenerative Medicine·P GiannoniR Cancedda
Feb 13, 2009·Biomaterials·Johannes C ReichertDietmar W Hutmacher
Jun 17, 2009·Tissue Engineering. Part a·Andrew Krishna EkaputraDietmar Werner Hutmacher
Oct 3, 2009·Tissue Engineering. Part B, Reviews·Johannes C ReichertDietmar W Hutmacher
Nov 7, 2009·Tissue Engineering. Part B, Reviews·George F MuschlerJeffrey O Hollinger
Dec 8, 2010·International Orthopaedics·Johannes C ReichertDietmar W Hutmacher
Jan 13, 2011·Veterinary and Comparative Orthopaedics and Traumatology : V.C.O.T·J R FieldS Itescu
Jul 16, 2011·International Journal of Biomaterials·Carlos A GarridoRacquel Z Legeros
Sep 14, 2011·Materials Science & Engineering. C, Materials for Biological Applications·Qiang FuAntoni P Tomsia
Jul 6, 2012·Science Translational Medicine·Johannes C ReichertDietmar W Hutmacher
Sep 4, 2012·Trends in Biotechnology·Susmita BoseAmit Bandyopadhyay
Oct 6, 2012·Acta Biomaterialia·Frédéric VelardPatrice Laquerriere
Feb 13, 2013·Injury·Thomas GoffPeter V Giannoudis
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Hawraa KariemChristian Hellmich
Nov 14, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jiao Jiao LiHala Zreiqat

❮ Previous
Next ❯

Citations

Dec 28, 2017·Advanced Healthcare Materials·Jiao Jiao LiHala Zreiqat
Jul 29, 2016·Journal of the Royal Society, Interface·Pamela L GraneyKara L Spiller
Mar 13, 2020·Journal of Orthopaedic Surgery and Research·Weiyang ZhongZhigang Wang
May 4, 2021·Advanced Healthcare Materials·Yiting LouBinbin Ying
Aug 11, 2021·Pharmaceutics·Dragana Bjelić, Matjaž Finšgar
Jan 25, 2022·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Katherine R Hixon, Anna N Miller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.