PMID: 18404122Apr 12, 2008Paper

Efficacy of omega-6 essential fatty acid treatment before and after photorefractive keratectomy

Journal français d'ophtalmologie
G QuerquesN Delle Noci

Abstract

Following PRK, a regression or the appearance of haze is often observed. This type of problem may be caused by an anomalous response by the stroma, probably mediated by keratocytes. Controlling keratocyte apoptosis therefore affects the outcome and stability of PRK. Inhibiting the transmission of the apoptosis signal from the damaged corneal epithelium to the keratocytes attenuates cell activation. This can be achieved by using a systemic product that will control the release of the mediators of the inflammation and stimulate tear production. The aim of this prospective, randomized study was to test the effects of a supplement containing omega-6 fatty acids (linoleic and (-linolenic acid), (-carotene, group B vitamins and trace elements (copper, zinc), when administered both before and after PRK. Eighty subjects undergoing PRK were randomly divided into two groups. The group treated with omega-6 fatty acids included 18 females and 22 males, with a mean age of 32 years; the control group comprised 20 females and 20 males (mean age, 30 years). Statistical evaluation of the results was carried out on Schirmer test and fluorescein staining values and the state of the epithelium. In the Schirmer tests, a comparison between the two g...Continue Reading

Citations

Dec 18, 2019·The Cochrane Database of Systematic Reviews·Laura E DownieEsen K Akpek

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis