Efficacy of once-daily indacaterol relative to alternative bronchodilators in COPD: a patient-level mixed treatment comparison

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Shannon CopeJeroen P Jansen

Abstract

Indacaterol was evaluated versus placebo, formoterol, and salmeterol in randomized controlled trials. No direct comparisons, however, are available for indacaterol 150 μg with formoterol or indacaterol 300 μg with salmeterol. Indacaterol trial evidence was synthesized to provide coherent estimates of indacaterol 150 μg and indacaterol 300 μg relative to formoterol, salmeterol, and tiotropium. Four randomized controlled trials were combined with Bayesian mixed treatment comparisons by using individual patient-level data. End points of interest were trough forced expiratory volume in 1 second (FEV(1)), St. George's Respiratory Questionnaire (SGRQ) total score and response (≥ 4 points), and Transition Dyspnea Index total score and response (≥ 1 point). Indacaterol 150 μg demonstrated a higher FEV(1) than did formoterol at 12 weeks and 6 months (0.10 L difference; 95% credible interval [CrI] = 0.06-0.14), as did indacaterol 300 μg versus salmeterol (0.06 L difference at 12 weeks; CrI = 0.02-0.10; 0.06 L at 6 months; CrI = 0.02-0.11). Regarding SGRQ, indacaterol 150 μg demonstrated a comparable proportion of responders versus formoterol, as did indacaterol 300 μg versus salmeterol. In comparison to tiotropium, indacaterol 150 μg dem...Continue Reading

References

Sep 11, 2001·American Journal of Respiratory and Critical Care Medicine·R DahlUNKNOWN Formoterol in Chronic Obstructive Pulmonary Disease I Study Group
Jan 29, 2002·Statistics in Medicine·Sander Greenland
Feb 28, 2002·The European Respiratory Journal·R CasaburiT Witek
Apr 12, 2002·Chest·Andrea RossiUNKNOWN Formoterol in Chronic Obstructive Pulmonary Disease (FICOPD) II Study Group
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Oct 15, 2005·BMJ : British Medical Journal·Deborah M CaldwellJ P T Higgins
Dec 12, 2007·Statistics in Medicine·Richard D RileyFlorent Boutitie
Feb 2, 2008·The European Respiratory Journal·M CazzolaUNKNOWN European Respiratory Society Task Force on outcomes of COPD
May 21, 2008·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Jeroen P JansenWiro Stam
Aug 30, 2008·Thorax·J Bourbeau, S J Bartlett
Jul 3, 2009·Current Medical Research and Opinion·Martyn R PartridgeIain R Small
Mar 10, 2010·BMC Pulmonary Medicine·Gregory FeldmanUNKNOWN INLIGHT 1 study group
Jun 15, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Jeroen P JansenJoseph C Cappelleri
Jun 15, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·David C HoaglinAnnabel Barrett

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Citations

Apr 13, 2013·Drugs & Aging·Timothy E AlbertsonAndrew L Chan
Oct 8, 2013·Respiratory Research·Shannon CopePaul Jones
Aug 8, 2013·International Journal of Chronic Obstructive Pulmonary Disease·Andrea Rossi, Guido Polese
Dec 20, 2013·International Journal of Chronic Obstructive Pulmonary Disease·Paschalis SteiropoulosDemosthenes Bouros
Aug 13, 2014·International Journal of Chronic Obstructive Pulmonary Disease·Neil S RoskellKarin Becker
Apr 28, 2016·BMC Medical Research Methodology·Areti Angeliki VeronikiAndrea C Tricco
Apr 25, 2020·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Shannon CopeJeroen Paul Jansen

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