Efficacy of ondansetron and metoclopramide for preventing postoperative emesis following strabismus surgery in children

Anaesthesia
D Shende, N G Mandal

Abstract

A double-blind, randomised, placebo-controlled trial was conducted to compare the efficacy of metoclopramide with the 5-HT3 antagonist, ondansetron, for the prevention of postoperative emesis in children undergoing elective strabismus surgery. None of the children received any premedication and a similar anaesthetic technique was used for all. Ondansetron 0.15 mg.kg-1, metoclopramide 0.25 mg.kg-1 or saline placebo were administered following intravenous catheter placement. Episodes of emesis were recorded for the first 24 h for the intervals of 0-2, 2-6 and 6-24 h. The incidence of emesis in the first 24 h was observed to be 71.7% in the placebo group, 34.4% in the ondansetron group (p < 0.001) and 61.4% in the metoclopramide group (p = NS). The severity of vomiting was less in the ondansetron group as compared with metoclopramide (p < 0.01) and placebo (p < 0.001). Recovery room scores were comparable in all the groups. No serious side-effects were observed in the ondansetron group. We conclude that prophylactic ondansetron is effective and superior to metoclopramide in the prevention of postoperative emesis in children following elective strabismus surgery.

Citations

Dec 21, 2000·Paediatric Anaesthesia·R DrakeJ M Thompson
Feb 18, 2009·Journal of Gastroenterology and Hepatology·Toru HiyamaKazuaki Chayama
Aug 12, 2006·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Christine M StorkLawrence H Brown
Mar 17, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H M MunroA R Tait
Apr 7, 2009·The Journal of Emergency Medicine·James E CollettiUNKNOWN ACEP Pediatric Emergency Medicine Committee
Mar 24, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Melissa Lau Moon LinL Lee Dupuis
Nov 5, 2016·Pediatric Emergency Care·Scott M Brenner, Jenny Boucher
Oct 23, 2002·Paediatric Drugs·Pasquale De Negri, Giorgio Ivani
Jul 18, 2017·The Cochrane Database of Systematic Reviews·John Carlisle, Carl A Stevenson
Apr 20, 2004·Journal of Pediatric Ophthalmology and Strabismus·Neerja BhardwajPramila Chari

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