PMID: 15253084Jul 16, 2004Paper

Efficacy of oral and intravenous dexamethasone in horses with recurrent airway obstruction

Equine Veterinary Journal
C J CornelisseF J Derksen

Abstract

Although the efficacy of dexamethasone for the treatment of recurrent airway obstruction (RAO) has been documented, the speed of onset of effect and duration of action are unknown, as is the efficacy of orally administered dexamethasone with or without fasting. To document the time of onset of effect and duration of action of a dexamethasone solution i.v. or orally with and without fasting. Protocol 1 used 8 RAO-affected horses with airway obstruction in a crossover design experiment that compared the effect of i.v. saline and dexamethasone (0.1 mg/kg bwt) on pulmonary function over 4 h. Protocol 2 used 6 similar horses to compare, in a crossover design, the effects of dexamethasone i.v. (0.1 mg/kg bwt), dexamethasone per os (0.164 mg/kg bwt) with and without prior fasting, and dexamethasone per os (0.082 mg/kg) with fasting. Dexamethasone i.v. caused significant improvement in lung function within 2 h with a peak effect at 4-6 h. Dexamethasone per os was effective within 6 h with peak effect at 24 h at a dose of 0.164 mg/kg bwt prior to feeding. The duration of effect was, for all dexamethasone treatments, statistically significant for 30 h when compared to saline and tended to have a longer duration of effect when used orally...Continue Reading

References

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Jul 11, 2002·Equine Veterinary Journal·D L PeroniN E Robinson

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Citations

Aug 10, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Mathilde LeclereJean-Pierre Lavoie
May 20, 2011·Equine Veterinary Journal·V GerberN E Robinson
Mar 16, 2017·Equine Veterinary Journal·L CalzettaM G Matera
Oct 30, 2013·Equine Veterinary Journal·R S Pirie
Sep 15, 2009·Journal of Veterinary Internal Medicine·N E RobinsonF J Derksen
Apr 6, 2021·Journal of Veterinary Internal Medicine·Selena de WasseigeJean-Pierre Lavoie
Jun 5, 2021·Journal of Veterinary Internal Medicine·Sophie Mainguy-Seers, Jean-Pierre Lavoie

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