Efficacy of oral and systemic antibiotic prophylaxis in colorectal operations

Archives of Surgery
R E CondonR M Vetto

Abstract

A cooperative Veterans Administration study of the septic complication rate during large-bowel surgery was undertaken in two groups of patients. The first group received oral neomycin and erythromycin base plus parenteral placebo; the second, the oral antibiotics plus parenteral cephalothin sodium. During a five-year period, 1,128 patients were studied. The overall septic complication rate was 7.8% in patients receiving only oral antibiotics, and 5.7% in patients receiving both oral and parenteral antibiotics. This difference was not significant. The only significant finding was a greater incidence of fever of unknown origin in patients receiving only oral antibiotics. None of those patients were treated with additional antibiotics, and all fevers cleared spontaneously. There seems to be no discernible benefit from adding parenteral antibiotic prophylaxis when performing elective colon surgery if appropriate mechanical cleansing and oral neomycin and erythromycin therapy are employed.

Citations

May 1, 1984·Annals of Surgery·G L IrvinJ A Caruana
Mar 7, 2013·Surgical Infections·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America (SHEA)
Jan 1, 1990·Diseases of the Colon and Rectum·D E Beck, V W Fazio
Oct 13, 2001·Diseases of the Colon and Rectum·O ZmoraS D Wexner
Jan 1, 1989·Diseases of the Colon and Rectum·I T KhubchandaniR D Riether
Jan 27, 2009·International Journal of Oral and Maxillofacial Surgery·D KosuticG Knezevic
Sep 1, 1987·Current Problems in Cancer·D I SoybelS A Wells
Oct 1, 1989·American Journal of Surgery·T R JonesR W Cantrell
May 31, 1988·American Journal of Surgery·D E Fry
May 15, 1984·The American Journal of Medicine·R L Nichols
Oct 1, 1989·American Journal of Infection Control·N J Ehrenkranz
Sep 28, 2014·Journal of the American College of Surgeons·Matthew D ZelhartRonald L Nichols
Feb 13, 2001·Annual Review of Medicine·J DaleyS F Khuri
Aug 16, 2016·Advances in Surgery·Alice Charlotte Adelaide Murray, Ravi P Kiran
Jun 1, 1992·The Australian and New Zealand Journal of Surgery·J C Hall, K Christiansen
Apr 29, 1999·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·A J MangramW R Jarvis
Sep 1, 1988·The British Journal of Surgery·Z H Krukowski, N A Matheson
May 13, 2014·The Cochrane Database of Systematic Reviews·Richard L NelsonMarija Barbateskovic
May 1, 1992·World Journal of Surgery·S Nivatvongs, B G Wolff
Nov 1, 1994·The Journal of Laryngology and Otology·M I Redleaf, C A Bauer
Aug 10, 2002·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Malcolm HiltonAndrew Simor
Mar 1, 1985·Drug Intelligence & Clinical Pharmacy·R P Rapp, D Blue
Feb 1, 1990·Diseases of the Colon and Rectum·J A Solla, D A Rothenberger
Sep 22, 2016·Langenbeck's Archives of Surgery·Michal MikAdam Dziki
May 1, 1987·Drug Intelligence & Clinical Pharmacy·L Danziger, E Hassan
Sep 1, 1984·Pharmacotherapy·T G Burnakis

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