Efficacy of oral antiviral drugs to prevent mother-to-child transmission of hepatitis B virus: a network meta-analysis.

Hepatology International
Fang JiaWenwei Yin

Abstract

Hepatitis B is a serious global health problem. Mother-to-child transmission (MTCT) of hepatitis B virus (HBV) is a major risk factor in the endemicity of HBV infection. Oral antiviral drugs are recommended to highly viremic mothers to decrease MTCT of HBV. The present network analysis compared the efficacy of available treatments to prevent the MTCT of HBV. The electronic databases of PubMed, Embase, Web of Science, Scopus, and Wanfang data were searched for eligible studies. Pair-wise meta-analysis and Bayesian network analysis were applied to compare the efficacy of antiviral drugs. Seventy-five studies involving 12,740 pregnant females were eligible for analysis. On pair-wise analysis, lamivudine (OR 0.15, 95% CI 0.09-0.25, I-squared = 0%), telbivudine (OR 0.07, 95% CI 0.05-0.10, I-squared = 0%) and tenofovir (OR 0.07, 95% CI 0.04-0.13, I-squared = 0%) significantly decreased the MTCT rate. Results of multiple comparisons with ranking probability based on Bayesian analysis showed that tenofovir (SUCRA = 96.83%) appeared more effective than the two other drugs. In addition to active and passive immunoprophylaxis, lamivudine, telbivudine and tenofovir in highly viremic mothers can further decrease MTCT of HBV. Based on direct...Continue Reading

References

Apr 10, 1975·The New England Journal of Medicine·C E StevensW C Lee
Dec 1, 1994·The Journal of Infectious Diseases·R D BurkR P Beasley
Apr 21, 2006·The Cochrane Database of Systematic Reviews·C LeeC Gluud
May 20, 2011·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Minmin YuNaiying Kan
Aug 24, 2011·Archives of Gynecology and Obstetrics·Jun KakogawaShigeki Minoura
Feb 22, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Calvin Q PanGen-Ju Wang
Jul 23, 2013·Virology Journal·Wolfram H Gerlich
Sep 18, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hua ZhangXin Liu
Sep 10, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Basile NjeiJoseph K Lim
Nov 14, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert S BrownKhaled Mohammed
Apr 22, 2017·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver
Feb 7, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Norah A TerraultJohn B Wong

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