Efficacy of oral ribavirin in lung transplant patients with respiratory syncytial virus lower respiratory tract infection.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Andres PelaezE Clinton Lawrence

Abstract

Respiratory syncytial virus (RSV) can cause severe lower respiratory tract infection (LRI) and is a risk factor for the development of bronchiolitis obliterans syndrome (BOS) after lung transplantation (LTx). Currently, the most widely used therapy for RSV is inhaled ribavirin. However, this therapy is costly and cumbersome. We investigated the utility of using oral ribavirin for the treatment of RSV infection after LTx. RSV was identified in nasopharyngeal swabs (NPS) or bronchoalveolar lavage (BAL) using direct fluorescent antibody (DFA) in 5 symptomatic LTx patients diagnosed with LRI. Data were collected from December 2005 and August 2007 and included: age; gender; type of LTx; underlying disease; date of RSV; pulmonary function prior to, during and up to 565 days post-RSV infection; need for mechanical ventilation; concurrent infections; and radiographic features. Patients received oral ribavirin for 10 days with solumedrol (10 to 15 mg/kg/day intravenously) for 3 days, until repeat NPS were negative. Five patients had their RSV-LRI diagnosis made at a median of 300 days post-LTx. Mean forced expiratory volume in 1 second (FEV(1)) fell 21% (p < 0.012) during infection. After treatment, FEV(1) returned to baseline and was m...Continue Reading

References

May 1, 1997·Bone Marrow Transplantation·E SparrelidJ Andersson
Feb 7, 2001·Journal of Computer Assisted Tomography·J P KoT C McLoud
Mar 19, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Marc EstenneSamuel Yousem
Jul 23, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Lewis H McCurdyStephen Dummer
Jul 6, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Deepali KumarAtul Humar
Dec 21, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Allan R GlanvilleMonique A Malouf

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Citations

Mar 2, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Patrizia Comoli, Fabrizio Ginevri
Jan 25, 2013·Journal of Natural Medicines·Katsuhiko KonnoMasahiko Kurokawa
Sep 13, 2012·Current Infectious Disease Reports·Defne Arslan, Lara Danziger-Isakov
Oct 23, 2013·Current Infectious Disease Reports·Dana HawkinsonLara Danziger-Isakov
Apr 1, 2010·Seminars in Respiratory and Critical Care Medicine·Pali Dedhiya Shah, John F McDyer
May 18, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Sergio R BurgueteStephanie M Levine
Nov 17, 2010·American Journal of Respiratory and Critical Care Medicine·Michael Boeckh, Janet A Englund
Feb 18, 2011·American Journal of Respiratory and Critical Care Medicine·Todd L Astor
Apr 10, 2013·Expert Review of Anti-infective Therapy·Diana F FlorescuUriel Sandkovsky
Jun 23, 2011·Expert Review of Anti-infective Therapy·Raymund R Razonable
Oct 11, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jens GottliebAllan R Glanville
Oct 14, 2014·The American Journal of the Medical Sciences·Andres PelaezDavid M Guidot
May 27, 2014·Infectious Disease Clinics of North America·Lilian M Abbo, Ella J Ariza-Heredia
Oct 24, 2012·Critical Care Nursing Clinics of North America·Judy Trivits Verger, Emily Elizabeth Verger
May 25, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Lily LiLara Danziger-Isakov
Oct 4, 2011·Mayo Clinic Proceedings·Raymund R Razonable
Apr 23, 2011·Clinics in Chest Medicine·Karen D Sims, Emily A Blumberg
Mar 1, 2011·Revue de pneumologie clinique·C KnoopM Estenne
May 15, 2010·Infectious Disease Clinics of North America·Deepali Kumar, Atul Humar
Apr 21, 2010·Revue des maladies respiratoires·C KnoopM Estenne
Oct 20, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ilker UçkayChristian van Delden
Nov 19, 2011·Transplant Infectious Disease : an Official Journal of the Transplantation Society·E J Ariza-HerediaL Abbo
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·O ManuelUNKNOWN AST Infectious Diseases Community of Practice
Mar 14, 2014·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J R MarcelinUNKNOWN Mayo Clinic Hematology/Oncology and Transplant Infectious Diseases Services
Jan 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M G IsonUNKNOWN AST Infectious Diseases Community of Practice
Feb 4, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A PelaezP O Mitchell
Sep 19, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·V LiuD Weill
Jun 28, 2015·Antiviral Research·Carrie W EvansJames W Noah
Mar 11, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Fay S BurrowsAllan R Glanville
Jun 13, 2015·Current Infectious Disease Reports·Kari Neemann, Alison Freifeld
Jul 20, 2014·Pulmonary Pharmacology & Therapeutics·Carolina ClajusMarco Mantero
Aug 1, 2015·The Annals of Pharmacotherapy·Alan E Gross, Michelle L Bryson
Apr 21, 2017·Expert Opinion on Pharmacotherapy·Shellee A GrimNina M Clark
Mar 8, 2012·The Annals of Pharmacotherapy·Lauren M Hynicka, Christopher R Ensor
Apr 24, 2018·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Dima Dandachi, Maria C Rodriguez-Barradas
Dec 3, 2016·Clinical Microbiology Reviews·Cameron GriffithsDavid J Marchant
Mar 1, 2019·Clinical Transplantation·Oriol ManuelUNKNOWN American Society of Transplantation Infectious Diseases Community of Practice
Aug 24, 2017·Critical Care Nursing Quarterly·Megan E GoetzTrisAnn Rendulic

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