Efficacy of oral tranexamic acid on blood loss in primary total hip arthroplasty using a direct anterior approach: a prospective randomized controlled trial

International Orthopaedics
HaiYan ZhaoPengde Kang

Abstract

Tranexamic acid (TXA), delivered intravenously or topically, has been shown to reduce blood loss, the need for transfusion, and relevant healthcare costs when administered in primary standard total hip arthroplasty (THA). Whether the same is true of oral TXA is unclear, the purpose of this study was to determine if oral tranexamic acid is equivalent to intravenous TXA in the case of patients undergoing THA via the direct anterior approach. In this prospective randomized controlled trial, 120 patients undergoing primary THA by the direct anterior approach were randomized to receive oral TXA (two doses of 20 mg/kg), intravenous TXA (two doses of 15 mg/kg), or no TXA. Primary outcomes were haemoglobin drop, haematocrit levels, total blood loss, intra-operative blood loss, need for transfusion, and volume transfused. Secondary outcomes included thromboembolic events, wound complications, the length of post-operative hospital stay, and 30-day readmission. Demographic characteristics were similar among the three patient groups (p > 0.05, n = 40 per group). Haemoglobin drop, haematocrit levels, total blood loss, and intra-operative blood loss were similar in the oral and intravenous groups (p > 0.05), and significantly smaller than in...Continue Reading

References

Mar 1, 1983·Anesthesiology·J B Gross
Jan 1, 1981·European Journal of Clinical Pharmacology·A PilbrantJ Vessman
Nov 1, 1993·The Journal of Bone and Joint Surgery. American Volume·A LaupacisR Bullas
Feb 1, 1996·Acta Orthopaedica Scandinavica·N E Sharrock, E A Salvati
Sep 26, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J F Hardy, S Bélisle
Jan 1, 1997·Seminars in Thrombosis and Hemostasis·S OkamotoU Okamoto
Feb 16, 2000·British Journal of Anaesthesia·A J JansenK Jochmans
Apr 4, 2007·The Journal of Bone and Joint Surgery. American Volume·Steven KurtzMichael Halpern
Apr 4, 2008·Revista española de anestesiología y reanimación·M A Camarasa GodoyE Palomera Fanegas
Jan 25, 2011·The Journal of Arthroplasty·Xudong LiuBingfang Zeng
Dec 14, 2011·The Journal of Bone and Joint Surgery. British Volume·S AlshrydaJ M Mason
May 25, 2012·The Journal of Bone and Joint Surgery. American Volume·Zhi-Gao YangLi-Dong Wu
Aug 3, 2012·Orthopaedics & Traumatology, Surgery & Research : OTSR·E IrissonF Kerbaul
Jul 28, 2013·The Journal of Arthroplasty·Blake P GilletteRafael J Sierra
Mar 19, 2014·The Journal of Arthroplasty·John R TuttleLee E Rubin
Apr 18, 2014·The Journal of Bone and Joint Surgery. American Volume·Steven M KurtzKevin J Bozic
Aug 27, 2014·The Journal of the American Academy of Orthopaedic Surgeons·Zachary D PostAlvin Ong
Nov 8, 2014·The Journal of Bone and Joint Surgery. American Volume·Karthikeyan E PonnusamyHarpal S Khanuja
Sep 9, 2015·Journal of Blood Medicine·Christopher KimJ Roderick Davey
May 20, 2016·The Journal of Bone and Joint Surgery. American Volume·Christian Skovgaard NielsenHenrik Husted
Mar 1, 2017·The Journal of Bone and Joint Surgery. American Volume·Erdan KayupovCraig J Della Valle

❮ Previous
Next ❯

Citations

Mar 13, 2019·Journal of Comparative Effectiveness Research·Lei WangJun Liu
Dec 10, 2019·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Osamu S KimuraMarco Bc Fernandes
Jul 31, 2019·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Nattapol TammachoteSupakit Kanitnate
May 8, 2020·International Orthopaedics·Stanislav PalijaDragana Dragicevic-Cvjetkovic
Jan 15, 2021·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Rodolfo Morales-AvalosFélix Vilchez-Cavazos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.