Efficacy of P11 -4 for the treatment of initial buccal caries: a randomized clinical trial

Scientific Reports
Paulina Sedlakova KondelovaIvo Krejci

Abstract

To investigate the safety and efficacy of Self-Assembling Peptide P11-4 (SAP P11-4) compared to placebo or fluoride varnish (FV), a randomized, controlled, blinded, split-mouth study with sequential design was conducted. Subjects presenting two teeth with White-Spot-Lesions (WSLs) were included and teeth were randomly assigned to test or control. Control received placebo at baseline (D0) and test SAP P11-4, all received FV at Day 90 (D90). Standardized photographs were taken at each visit, and WSL size changes were morphometrically assessed. Hierarchical Linear Modelling, considering paired and sequential design, was used to test four hypotheses. SAP P11-4 lesions (test, D90-D0) showed significant WSL size reduction compared to placebo (control, D90-D0; p = 0.008) or FV (control, D180-D90; p = 0.001). Combination of SAP P11-4 and delayed FV after 90 days (test, D180-D0), showed a significant difference compared to FV alone (control D270-D90; p = 0.003). No significant difference on FV efficacy was found when SAP P11-4 was applied 3 months before FV (test D270-D90; control D270-D90, p = 0.70). SAP P11-4 treatment resulted in superior caries regression compared to either placebo or FV, and FV efficacy seems not to be affected by ...Continue Reading

References

Sep 1, 1966·Journal of Dental Research·G Bergman, P O Lind
Feb 1, 1982·American Journal of Orthodontics·L GorelickA J Gwinnett
Apr 25, 2007·Journal of Dental Research·J KirkhamA Aggeli
May 24, 2007·Community Dentistry and Oral Epidemiology·A I IsmailN B Pitts
Sep 1, 2009·Advances in Dental Research·J D B Featherstone
May 28, 2010·Journal of Dental Research·S ParisH Meyer-Lueckel
Nov 26, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Frank MüllerKarin Jacobs
Feb 24, 2012·The Angle Orthodontist·Mehmet Akin, Faruk Ayhan Basciftci
Dec 4, 2012·The Journal of the American Dental Association·Sonia K MakhijaUNKNOWN National Dental Practice-Based Research Network Collaborative Group
Jan 1, 2013·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Greg J HuangJack C Matunas
Jul 3, 2013·Monographs in Oral Science·Bennett T Amaechi, Cor van Loveren
Nov 2, 2014·The Journal of the American Dental Association·Sonia K MakhijaUNKNOWN National Dental PBRN Collaborative Group
Mar 24, 2016·Journal of Applied Oral Science : Revista FOB·Patrick SchmidlinFlorian Wegehaupt
Dec 3, 2016·European Journal of Orthodontics·Damian HöchliTheodore Eliades
Mar 28, 2017·Journal of Dental Research·L KindU Pieles
Sep 12, 2017·Journal of Dental Research·M AlkilzyC H Splieth
Jan 23, 2018·Advances in Dental Research·M AlkilzyC H Splieth
Jan 23, 2018·Advances in Dental Research·J D B Featherstone, B W Chaffee
Jan 23, 2018·Advances in Dental Research·C González-Cabezas, C E Fernández
Oct 10, 2015·Dentistry Journal·Hans DeyhleBert Müller

❮ Previous
Next ❯

Citations

Jun 25, 2021·Frontiers in Bioengineering and Biotechnology·Sharanya SankarLisa Spirio

❮ Previous
Next ❯

Methods Mentioned

BETA
Fluorescence
pregnancy test

Clinical Trials Mentioned

NCT02020681

Software Mentioned

STATA
Image J
SPSS Statistics

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.